Inhaled and oral salbutamol in exercise-induced asthma.
Inhaled and oral salbutamol in exercise-induced asthma.
复制标题
吸入和口服沙丁胺醇治疗运动诱发的哮喘。
DOI：
10.1164/arrd.1976.114.3.493
复制
发表时间：
1976
期刊：
影响因子：
--
通讯作者：
D. Lindsay
中科院分区：
文献类型：
--
作者：
S. Anderson;J. Seale;P. Rozea;L. Bandler;G. Theobald;D. Lindsay
Twenty-one asthmatic patients participated in a single blind, crossover study comparing the effects of aerosol and oral salbutamol (a beta-adrenergic bronchodilator), on exercise-induced bronchospasm. By both routes of administration, salbutamol (albuterol) produced significant bronchodilatation at rest, but only the aerosol effectively prevented post-exercise bronchospasm in most patients. Because exercise-induced bronchospasm is a common problem in children and adults with asthma, these observations are relevant to the drug therapy of these patients. The existence of separate mechanisms for bronchodilatation and the prevention of exercise-induced asthma is postulated. It is possible that differing tissue concentrations of salbutamol are responsible for the observed differences between the 2 routes of administration.
