Atopic dermatitis from adolescence to adulthood in the TOACS cohort: prevalence, persistence and comorbidities
Atopic dermatitis from adolescence to adulthood in the TOACS cohort: prevalence, persistence and comorbidities
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DOI：
10.1111/all.12619
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发表时间：
2015-07-01
期刊：
影响因子：
12.4
通讯作者：
Bindslev-Jensen, C.
中科院分区：
文献类型：
--
作者：
Mortz, C. G.;Andersen, K. E.;Bindslev-Jensen, C.
背景
虽然对儿童期特应性皮炎了解颇多，但对其持续至成年期的情况却知之甚少。据我们所知，我们首次报告了一组未经选择的青少年队列随访至成年期的特应性皮炎临床病程。
方法
对1995年建立的一组未经选择的八年级学生进行前瞻性研究，通过问卷调查和临床检查在2010年进行随访，以了解从青少年到成年期特应性皮炎的病程。
结果
特应性皮炎的终生患病率较高（34.1%），相当数量的成年人仍然患有特应性皮炎，通过问卷调查（17.1%）和临床检查（10.0%）评估均如此。在学龄期确诊的患者中，50%的人特应性皮炎持续存在，且持续性特应性皮炎与发病早、儿童期过敏性鼻炎和手部湿疹显著相关。还发现与过敏性接触性皮炎以及对糠秕马拉色菌特异性IgE升高密切相关，但与丝聚蛋白基因缺陷无关。
结论
成年期特应性皮炎持续存在较为常见，且影响生活质量。在儿童期发病早、有过敏性鼻炎和手部湿疹的人群中，持续性特应性皮炎尤为普遍。认识到特应性皮炎不仅在儿童中，而且在成年人中也是一种常见的致残性疾病非常重要。
BackgroundWhile much is known about childhood atopic dermatitis, little is known about persistence of atopic dermatitis into adult life. We report, to our knowledge for the first time, the clinical course of atopic dermatitis in an unselected cohort of adolescents followed into adulthood.MethodsThe course of atopic dermatitis from adolescence to adulthood was studied prospectively in a cohort of unselected 8th-grade schoolchildren established in 1995 and followed up in 2010 with questionnaire and clinical examination.ResultsThe lifetime prevalence of atopic dermatitis was high (34.1%), and a considerable number of adults still suffered from atopic dermatitis evaluated both by questionnaire (17.1%) and clinical examination (10.0%). Persistent atopic dermatitis was found in 50% of those diagnosed in school age, and persistent atopic dermatitis was significantly associated with early onset, childhood allergic rhinitis and hand eczema. A close association was also found with allergic contact dermatitis and increased specific IgE to Malassezia furfur, but not with filaggrin gene defect.ConclusionPersistence of atopic dermatitis in adulthood is common and affects quality of life. Persistent atopic dermatitis is particularly prevalent in those with early onset, allergic rhinitis and hand eczema in childhood. It is important to recognizing atopic dermatitis as a common and disabling disease not only in children but also in adults.