DNA Loci Cross-Talk through Thermodynamics
DNA Loci Cross-Talk through Thermodynamics
复制标题
通过热力学进行 DNA 位点串扰
DOI：
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发表时间：
2009
影响因子：
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通讯作者：
M. Nicodemi
中科院分区：
文献类型：
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作者：
A. Scialdone;M. Nicodemi
特定DNA位点的识别和配对，虽然对许多重要的细胞过程至关重要，但仍然是由神秘的物理机制产生的。我们从统计力学中提出了第一个定量模型，能够澄清允许这种“DNA串扰”事件的相互作用。结合某些DNA识别序列的可溶性分子在遥远的DNA位点之间产生有效的吸引力;如果它们的亲和力、浓度和相对DNA结合位点数超过给定的阈值，则由于热力学相变而发生DNA共定位。在本文中，经过一些最近的实验结果的简要报告，我们介绍了我们的模型，并进行了详细的“在硅片上”的分析，通过蒙特卡罗模拟。我们的研究，同时合理化几个实验观察，导致非常有趣和可检验的预测。
The recognition and pairing of specific DNA loci, though crucial for a plenty of important cellular processes, are produced by still mysterious physical mechanisms. We propose the first quantitative model from Statistical Mechanics, able to clarify the interaction allowing such “DNA cross-talk” events. Soluble molecules, which bind some DNA recognition sequences, produce an effective attraction between distant DNA loci; if their affinity, their concentration, and the relative DNA binding sites number exceed given thresholds, DNA colocalization occurs as a result of a thermodynamic phase transition. In this paper, after a concise report on some of the most recent experimental results, we introduce our model and carry out a detailed “in silico” analysis of it, by means of Monte Carlo simulations. Our studies, while rationalize several experimental observations, result in very interesting and testable predictions.
影响因子：
16
作者：
Donohoe, Mary E.;Zhang, Li-Feng;Lee, Jeannie T.
通讯作者：
Lee, Jeannie T.
影响因子：
16
作者：
Jing, Huie;Vakoc, Christopher R.;Blobel, Gerd A.
通讯作者：
Blobel, Gerd A.