Hospital outbreak of Middle East respiratory syndrome coronavirus.
Hospital outbreak of Middle East respiratory syndrome coronavirus.
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DOI：
10.1056/nejmoa1306742
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发表时间：
2013-08-01
期刊：
影响因子：
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通讯作者：
KSA MERS-CoV Investigation Team
中科院分区：
文献类型：
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作者：
Assiri A;McGeer A;Perl TM;Price CS;Al Rabeeah AA;Cummings DA;Alabdullatif ZN;Assad M;Almulhim A;Makhdoom H;Madani H;Alhakeem R;Al-Tawfiq JA;Cotten M;Watson SJ;Kellam P;Zumla AI;Memish ZA;KSA MERS-CoV Investigation Team
2012年9月，世界卫生组织报道了新型中东呼吸综合症冠状病毒（MERS-COV）引起的肺炎的第一批病例。
对临床和人口统计信息进行了审查，并确定了潜在的接触和暴露于病例的病例被测序。
在2013年4月1日至5月23日之间，在沙特阿拉伯的东部总共有23例MERS-COV感染。呼吸为11（48％），胃肠道症状为8（35％）；截至6月12日，胸部射线照片异常（87％）。 ％）恢复了，其中2个（9％）仍住院。中位孵育期为5.2天（95％置信区间[CI]，1.9至14.7），串行间隔为7.6天（95％CI，2.5至23.1）。在23个病例中，总共有21个是通过人与人的传播在血液透析单元，重症监护病房或三个不同医疗机构中的住院单位中获得的。我们确定的217个家庭联系人和200多名卫生保健工作者之间的单一单枝。 ）。
MERS-COV的人对人的传播可能会在医疗保健环境中发生，并且可能与可观的发病率有关。
In September 2012, the World Health Organization reported the first cases of pneumonia caused by the novel Middle East respiratory syndrome coronavirus (MERS-CoV). We describe a cluster of health care–acquired MERS-CoV infections. Medical records were reviewed for clinical and demographic information and determination of potential contacts and exposures. Case patients and contacts were interviewed. The incubation period and serial interval (the time between the successive onset of symptoms in a chain of transmission) were estimated. Viral RNA was sequenced. Between April 1 and May 23, 2013, a total of 23 cases of MERS-CoV infection were reported in the eastern province of Saudi Arabia. Symptoms included fever in 20 patients (87%), cough in 20 (87%), shortness of breath in 11 (48%), and gastrointestinal symptoms in 8 (35%); 20 patients (87%) presented with abnormal chest radiographs. As of June 12, a total of 15 patients (65%) had died, 6 (26%) had recovered, and 2 (9%) remained hospitalized. The median incubation period was 5.2 days (95% confidence interval [CI], 1.9 to 14.7), and the serial interval was 7.6 days (95% CI, 2.5 to 23.1). A total of 21 of the 23 cases were acquired by person-to-person transmission in hemodialysis units, intensive care units, or in-patient units in three different health care facilities. Sequencing data from four isolates revealed a single monophyletic clade. Among 217 household contacts and more than 200 health care worker contacts whom we identified, MERS-CoV infection developed in 5 family members (3 with laboratory-confirmed cases) and in 2 health care workers (both with laboratory-confirmed cases). Person-to-person transmission of MERS-CoV can occur in health care settings and may be associated with considerable morbidity. Surveillance and infection-control measures are critical to a global public health response.