Posttraumatic mossy fiber sprouting is related to the degree of cortical damage in three mouse strains.
Posttraumatic mossy fiber sprouting is related to the degree of cortical damage in three mouse strains.
复制标题
DOI：
10.1016/j.eplepsyres.2011.10.011
复制
发表时间：
2012-03
影响因子：
2.2
通讯作者：
Smith BN
中科院分区：
文献类型：
--
作者：
Hunt RF;Haselhorst LA;Schoch KM;Bach EC;Rios-Pilier J;Scheff SW;Saatman KE;Smith BN
采用控制性皮质撞击伤，研究了三种小鼠齿状回苔藓纤维发芽（MFS）与局部创伤后皮质损伤的关系。创伤后MFS是更强大的皮质损伤时，冲击海马，与挫伤仅限于新皮质，和CD-1，C57 BL/6，和FVB/N背景菌株之间的定性相似。影响损伤严重程度的冲击参数在神经创伤模型中再现癫痫相关变化可能是至关重要的。
Controlled cortical impact injury was used to examine relationships between focal posttraumatic cortical damage and mossy fiber sprouting (MFS) in the dentate gyrus in three mouse strains. Posttraumatic MFS was more robust when cortical injury impinged upon the hippocampus, versus contusions restricted to neocortex, and was qualitatively similar among CD-1, C57BL/6, and FVB/N background strains. Impact parameters influencing injury severity may be critical in reproducing epilepsy-related changes in neurotrauma models.