Amyloid precursor-like protein 1 accumulates in neuritic plaques in Alzheimer's disease
Amyloid precursor-like protein 1 accumulates in neuritic plaques in Alzheimer's disease
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DOI：
10.1007/s004010050745
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发表时间：
1997-12-01
影响因子：
12.7
通讯作者：
Multhaup, G
中科院分区：
文献类型：
--
作者：
Bayer, TA;Paliga, K;Multhaup, G
阿尔茨海默病(AD) β -淀粉样前体蛋白（APP）和淀粉样前体样蛋白1 （APLP1）和2 （APLP2）是一个功能相关的蛋白质超家族的成员。尽管APLPs在Nand c端结构域与APP高度同源，但它们缺乏β A4/淀粉样蛋白肽，即AD神经斑块的主要成分。为了评估APLP1在AD中的潜在作用，我们确定了其在AD中受强烈影响的人类海马结构中的免疫组织化学分布，并将其与APP的免疫反应性进行了比较。APP和APLP1的区域表达模式有相当大的重叠。在神经性斑块中观察到显著的APLP1免疫反应性。耻骨下的大锥体神经元在树突腔室中显示APLP1蛋白的积累。一些星形胶质细胞引起核周APLP1染色，但在AD和对照脑中均观察到这种情况。这些发现提出了APLP1可能参与ad相关神经变性发病机制的可能性。
The Alzheimer's disease (AD) beta-amyloid precursor protein (APP) and the amyloid precursor-like protein 1 (APLP1) and 2 (APLP2) are members of a superfamily of proteins that appear functionally related. Although APLPs are highly homologous to APP in the Nand C-terminal domains, they lack the beta A4/amyloid peptide, i.e., the main constituent of neuritic plaques in AD. To assess a potential role of APLP1 in AD, we have determined its immunohistochemical distribution in human hippocampal formation, a structure which is strongly affected in AD, and compared it with APP immunoreactivity. There was a considerable overlap of APP and APLP1 regional expression patterns. Significant APLP1 immunoreactivity was observed in neuritic plaques. Large pyramidal neurons of the subiculum showed an accumulation of APLP1 protein in their dendritic compartment. Some astrocytes elicited perinuclear APLP1 staining, but this was observed in both AD and control brains. These findings raise the possibility that APLP1 may contribute to the pathogenesis of AD-associated neurodegeneration.