Association of a Vascular Endothelial Growth Factor genetic variant with Serum VEGF level in subjects with Metabolic Syndrome
Association of a Vascular Endothelial Growth Factor genetic variant with Serum VEGF level in subjects with Metabolic Syndrome
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DOI：
10.1016/j.gene.2016.10.034
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发表时间：
2017-01-20
期刊：
影响因子：
3.5
通讯作者：
Ghayour-Mobarhan, Majid
中科院分区：
文献类型：
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作者：
Ghazizadeh, Hamideh;Fazilati, Mohammad;Ghayour-Mobarhan, Majid
背景：代谢综合征(METS)是一组代谢紊乱的聚集性疾病，与心血管疾病、糖尿病和相关疾病的风险增加有关。在此背景下，血管内皮细胞生长因子(VEGF)在血管生成、血管通透性和造血方面发挥着重要作用，其水平的升高被报道与增加心血管疾病、中风和糖尿病的风险有关。因此，本研究的目的是探讨850例有/无代谢综合征患者血清血管内皮生长因子水平及其相关的基因多态性rs10738760(A>；G)9p24.2之间的关系。采用聚合酶链式反应-扩增难治突变系统进行基因分型。结果：METS患者的BMI、腰围、胆固醇、甘油三酯、超敏C反应蛋白、收缩压/舒张压明显高于对照组(P<0.05)，而高密度脂蛋白胆固醇明显低于对照组(P<0.05)。此外，我们的分析显示，携带GA或AA基因的METS患者的血清VEGFF水平显著升高(P=0.03)。结论：我们证实了VEGF基因变异与METS的关联，提示其可能是METS的危险分层因素。(C)2016爱思唯尔B.V.保留所有权利。
Background: The metabolic syndrome (MetS) is a clustering of metabolic disorders that is associated with an increased risk of developing cardiovascular-disease, diabetes, and related diseases. Against this background, Vascular Endothelial Growth Factor (VEGF) plays an essential role in angiogenesis, vascular permeability, and hematopoiesis and its increased level is reported to be associated with increasing the risk of developing cardiovascular-disease, stroke and diabetes. Therefore the aim of present study was to explore the association of serum VEGF level and its associated genetic-polymorphism, rs10738760 (A>G) at 9p24.2, in 850 subjects with/without MetS.Methods: MetS was defined according to the International-Diabetes-Federation criteria. Genotyping was carried out using Polymerase chain reaction-amplification refractory mutation system. Anthropometric/biochemical parameters, including FBG, Triglyceride, HDL, TC, etc., were determined followed by univariate and multivariate analyses.Results: MetS patients had significantly higher levels of BMI, waist-circumference, cholesterol, triglyceride, Hs-CRP and SBP/DBP, while the HDL-C levels was lower in patients group, compared to control group (P < 0.05). Moreover, our analysis showed that MetS patients with GA or AA genotypes had a significantly (P = 0.03) higher serum level of VEGF.Conclusions: we demonstrate an association between a VEGF genetic variant with MetS, suggesting its role as a risk stratification factor for MetS. (C) 2016 Elsevier B.V. All rights reserved.