OBSERVATIONS ON THE USE OF FERROMAGNETIC IMPLANTS FOR INDUCING HYPERTHERMIA
OBSERVATIONS ON THE USE OF FERROMAGNETIC IMPLANTS FOR INDUCING HYPERTHERMIA
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DOI：
10.1109/tbme.1984.325373
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发表时间：
1984-01-01
影响因子：
4.6
通讯作者：
ROEMER, RB
中科院分区：
文献类型：
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作者：
STAUFFER, PR;CETAS, TC;ROEMER, RB
铁磁植入物的磁感应加热可用于在深部肿瘤中产生高度局部化的热疗。我们讨论了表征这种方法的物理参数，并从动物的初步临床研究中给出了说明。研究的物理参数包括磁场强度、频率、负载大小、磁场均匀性、线圈设计以及植入物材料和配置的加热电位。与我们的实验结果一致的计算预测的最大加热频率的顺序为500 kHz的大横截面负载，如人的腹部，和1.9 MHz的较小的负载，如人脑。本文介绍了一种用于精确定量评价凝胶体模介质中铁磁材料加热电位的实验技术。根据每单位植入物长度的加热效率（ηL）分析这些数据，η L本身是植入物长度、直径、退火状态和磁场方向的函数。螺旋片线圈设计进行了说明，并给出了建议，为适当的电场屏蔽感应线圈的临床应用。对铁磁材料的注入技术也作了简要的讨论。最后，几个在体内的动物研究，以说明使用的技术治疗肿瘤的骨盆，胸部，口咽部，和大脑。
Magnetic induction heating of ferromagnetic implants can be used to produce highly localized hyperthermia in deep seated tumors. We discuss the physical parameters which characterize this method and give illustrations from initial clinical investigations in animals. The physical parameters studied include magnetic field strength, frequency, load size, field uniformity, coil designs, and the heating potential of implant materials and configurations. Calculations consistent with our experimental results predict a maximum heating frequency of the order of 500 kHz for large cross-sectional loads, such as the human abdomen, and 1.9 MHz for smaller loads, such as the human brain. An experlhnental technique is introduced for accurate quantitative evaluation of the heating potentials of ferromagnetic materials in a gelled phantom medium. These data are analyzed in terms of heating efficiency per unit implant length (ηL), which is itself a function of implant length, diameter, annealed state, and orientation with respect to the magnetic field. A spiral sheet coil design is described and recommendations are given for proper E-Field shielding of induction coils for clinical applications. A brief discussion of techniques of implanting the ferromagnetic materials is also given. Finally, several in vivo animal studies are presented to illustrate the use of the technique for treating tumors in pelvis, thorax, oral-pharynx, and brain.