Actions of opioids on primate spinothalamic tract neurons
Actions of opioids on primate spinothalamic tract neurons
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DOI：
10.1523/jneurosci.06-09-02509.1986
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发表时间：
1986-09
期刊：
影响因子：
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通讯作者：
WS Willcockson;J. Kim;H. Shin;J. Chung;W. Willis
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文献类型：
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作者：
WS Willcockson;J. Kim;H. Shin;J. Chung;W. Willis
在12只麻醉猴子的24个脊髓丘脑束细胞上，研究了离子导电阿片类药物的作用。所使用的药物是根据它们对不同类型阿片受体（mu，吗啡；kappa，啡啡肽；delta，蛋氨酸脑啡肽；sigma， n -烯丙基去甲氧唑嗪或SKF 10047和苯环利定）的激动作用而选择的。阿片类药物的作用通常是抑制性的，尽管有时也有兴奋性或混合作用，特别是与吗啡和啡的作用。药物作用可能会改变，这取决于离子电泳电极阵列的位置或所使用的电流。纳洛酮有时会拮抗所使用的阿片类药物的作用，但纳洛酮似乎不是一种适合离子渗透应用的药物。讨论了一些解释来解释阿片类药物的可变作用。
The effects of iontophoretically applied opiates were tested on 24 spinothalamic tract cells in 12 anesthetized monkeys. The drugs used were chosen because of their agonist actions on different classes of opiate receptors (mu, morphine; kappa, dynorphin; delta, methionine enkephalinamide; sigma, N-allylnormetazocine or SKF 10047 and phencyclidine). The actions of the opiate drugs were generally inhibitory, although excitatory or mixed effects were sometimes seen, especially with morphine and dynorphin. Drug effects could change, depending on the position of the iontophoretic electrode array or on the current employed. Naloxone sometimes antagonized the action of the opiate drugs used, but naloxone did not seem to be a drug suited for iontophoretic application. A number of explanations are discussed to explain the variable actions of the opiate drugs.