The Multiaspect Functions of Periostin in Tumor Progression
The Multiaspect Functions of Periostin in Tumor Progression
复制标题
Periostin在肿瘤进展中的多方面功能
DOI：
10.1007/978-981-13-6657-4_13
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Ouyang, Gaoliang
中科院分区：
文献类型：
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作者：
Liu, Yingfu;Huang, Zhengjie;Ouyang, Gaoliang
细胞外基质蛋白periostin在多种肿瘤中高表达，在肿瘤的发生发展中起重要作用。骨膜蛋白主要由肿瘤相关成纤维细胞、肌成纤维细胞、成骨细胞和骨髓源间充质间质细胞等基质细胞分泌。但在某些情况下，肿瘤细胞，尤其是癌症干细胞，也可以产生骨膜蛋白。研究表明，Periostin可调控肿瘤细胞的增殖、存活、侵袭、血管生成、转移和化疗耐药等多种生物学行为。此外，过多的骨膜蛋白沉积在肿瘤各种微环境的重塑中发挥着关键作用，如肿瘤干细胞生态位、血管周围生态位、转移前生态位、免疫抑制微环境、骨髓微环境等肿瘤生长支持微环境。在这篇综述中，我们提供了对骨膜蛋白在肿瘤发生和发展中的多方面功能和机制的最新认识。
Extracellular matrix protein periostin is highly expressed in various tumors and plays a critical role in tumor development and progression. Periostin is mainly secreted by stromal cells such as cancer-associated fibroblasts, myofibroblasts, osteoblasts and bone marrow-derived mesenchymal stromal cells. But in some cases, tumor cells, especially cancer stem cells, can also produce periostin. Periostin has been shown to regulate multiple biological behaviors of tumor cells, including proliferation, survival, invasion, angiogenesis, metastasis and chemoresistance. Moreover, an excessive periostin deposition exerts a pivotal role in remodeling various tumor microenvironments, such as cancer stem cell niche, perivascular niche, premetastatic niche, immunosuppressive microenvironment, bone marrow microenvironment and other tumor growth-supportive microenvironments. In this review, we provide an update understanding of the multifaceted functions and mechanisms of periostin in tumor development and progression.