Sensitivity of muscle force estimates to variations in muscle-tendon properties
Sensitivity of muscle force estimates to variations in muscle-tendon properties
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DOI：
10.1016/j.humov.2007.01.008
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发表时间：
2007-04-01
影响因子：
2.1
通讯作者：
Pandy, Marcus G.
中科院分区：
文献类型：
--
作者：
Redl, Christian;Gfoehler, Margit;Pandy, Marcus G.
本研究的目的是确定肌肉力估计对一些常用于描述肌肉肌腱驱动模型的参数变化的敏感性。对三个参数进行敏感性分析：最佳肌纤维长度、肌肉生理横截面积（PCSA）和肌腱静止长度。选择用于分析的肌肉是臀中肌/臀后肌、臀肌、比目鱼肌和缝匠肌。每个参数都偏离其标称值，并解决优化问题以确定每个参数对肌肉力计算值的相对影响。计算模拟正常行走周期的肌肉力量。使用两个新指标来量化参数灵敏度：综合灵敏度比，它量化了改变任何肌肉的单个参数对该肌肉产生的力的时间历史的影响；以及缩小的交叉敏感度比率，它量化了改变任何肌肉的一个参数对所有其他肌肉产生的力的时间历史的影响。结果表明，步行时的肌肉力量估计对肌腱静止长度的变化最敏感，而对肌肉 PCSA 的变化最不敏感。例如，对于比目鱼肌，肌腱静止长度的综合敏感度比肌纤维长度和 PCSA 的综合敏感度大一个数量级。对于vasti，肌腱静止长度的综合灵敏度比是肌纤维长度的两倍，并且比PCSA 的综合灵敏度高出近一个数量级。总体而言，股肌和比目鱼肌肌腱静止长度的变化以及股肌纤维长度的变化对于肌肉力量的模型估计最为关键。我们的结果强调了准确估计肌腱静止长度和肌纤维长度的重要性，特别是对于那些在运动过程中充当原动机的执行器（臀大肌、臀中肌/臀小肌、臀肌、比目鱼肌和腓肠肌）。 (C) 2007 Elsevier B.V. 保留所有权利。
The aim of this study was to determine the sensitivity of muscle force estimates to changes in some of the parameters which are commonly used to describe models of muscle-tendon actuation. The sensitivity analysis was performed on three parameters: optimal muscle-fiber length, muscle physiological cross-sectional area (PCSA), and tendon rest length. The muscles selected for the analysis were posterior gluteus medius/minimus, vasti, soleus, and sartorius. Each parameter was perturbed from its nominal value, and an optimization problem was solved to determine the relative influence of each parameter on the calculated values of muscle force. Muscle forces were calculated for a simulated cycle of normal walking. Parameter sensitivity was quantified using two new metrics: an integrated sensitivity ratio, which quantified the effect of changing a single parameter for any muscle on the time history of force developed by that muscle; and a slimmed cross-sensitivity ratio, which quantified the effect of changing one parameter for any muscle on the time histories of forces developed by all of the other muscles. The results showed that muscle force estimates for walking are most sensitive to changes in tendon rest length and least sensitive to changes in muscle PCSA. For soleus, for example, the integrated sensitivity ratios for tendon rest length were an order of magnitude greater than those for muscle-fiber length and PCSA. For vasti, the integrated sensitivity ratios for tendon rest length were twice as large as those for muscle-fiber length and nearly an order of magnitude greater than those for PCSA. Overall, changes in the tendon rest lengths of vasti and soleus and changes in the fiber length of vasti were most critical to model estimates of muscle force. Our results emphasize the importance of obtaining accurate estimates of tendon rest length and muscle-fiber length, particularly for those actuators that function as prime movers during locomotion (gluteus maximus, gluteus medius/minimus, vasti, soleus, and gastrocnemius). (C) 2007 Elsevier B.V. All rights reserved.