HSP70s: From Tumor Transformation to Cancer Therapy.
HSP70s: From Tumor Transformation to Cancer Therapy.
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DOI：
10.4137/cmo.s475
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Huang CM
中科院分区：
文献类型：
--
作者：
Shu CW;Huang CM
热休克蛋白 (HSP) 是一组确定的伴侣，用于维持蛋白质的正常功能。 HSP70 家族是对应激反应最易诱导的家族之一，可保护细胞免受应激诱导的细胞死亡。据记载，HSP70在各种类型的癌细胞中高表达，并使细胞能够抵抗不良微环境，例如缺氧和葡萄糖饥饿，这是恶性进展的常见特征。因此，HSP70 的过度表达与肿瘤转化相关，并最终导致化疗效果下降。值得注意的是，HSP70 在癌细胞中的分布失调。据报道，HSP70 在癌症发展过程中定位不同的细胞器或输出到体液循环。表面或输出的 HSP70 会发出危险信号并触发免疫反应来破坏肿瘤细胞。在这篇综述中，我们列出了 HSP70 介导的癌症诊断和治疗的最新进展。这篇综述将对临床癌症医学具有启发意义。
Heat shock proteins (HSPs) are a defined set of chaperones for maintaining proper functions of proteins. The HSP70 family, one of the most inducible families in response to stress, protects cells from stress-induced cell death. It has been documented that HSP70s are highly expressed in various types of cancer cells and make the cells resistant to adverse microenvironments, such as hypoxia and glucose starvation, which are common features in malignant progression. Over-expression of HSP70s is thus associated with tumor transformation and eventually results in a decrease of chemotherapy efficacy. Notably, the distribution of HSP70s is deregulated in cancer cells. It has been reported that HSP70s localize distinct organelles or are exported to humoral circulation during cancer development. Either surface or exported HSP70s play danger signals and trigger immune response to destroy the tumor cells. In this review, we lay out recent advances in the HSP70s-mediated cancer diagnosis and therapy. This review would be enlightening for clinical cancer medicine.