Assessing changes in tumour vascular function using dynamic contrast-enhanced magnetic resonance imaging
Assessing changes in tumour vascular function using dynamic contrast-enhanced magnetic resonance imaging
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DOI：
10.1002/nbm.756
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发表时间：
2002-04-01
影响因子：
2.9
通讯作者：
Leach, MO
中科院分区：
文献类型：
--
作者：
Hayes, C;Padhani, AR;Leach, MO
动态对比增强MRI（DCE-MRI）广泛用于癌症的诊断和分期，并正在成为一种有前途的监测肿瘤对治疗反应的方法。然而，DCE-MR成像技术仍在发展，图像分析方法仍然是可变的和非标准的。并且范围从增强模式的相对机会到造影剂摄取的药代动力学建模。因此，很难将不同机构的结果结合起来，而且还没有比较不同方法的灵敏度。本研究的目的是探讨定性和定量的相关性。对接受新辅助化疗的乳腺癌患者的DCE-MR图像进行定量分析。15例患者在化疗前和化疗1个疗程后均行DCE-MRI检查。信号增强时间模式的变化。增强的速率和幅度以及血浆与血管外细胞外间隙（EES）之间的造影剂体积转移常数。确定K-transs和EES体积分数v（e）。另外。将孔肿瘤感兴趣区域分析与直方图分析进行比较，以研究肿瘤异质性的程度。结果发现，增强率的变化与K-transs值的变化密切相关（Kendall τ = 0.68）。P < 0.001），此外。发现信号增强曲线的形状仅在K-transs值改变50%或更多时才改变。K-transs像素图直方图分析后确定的中位K-transs值约等于整个肿瘤相关分析确定的值。K-transs值的绝对变化与预处理值呈负相关。特别是对于有反应的病人。就这样。对于较高的预处理K-transs值。如观察到的更大的下降。在一个疗程后，观察到K-transs直方图的上限变化大于中值变化。版权所有（C）2002年约翰威利儿子。公司
Dynamic contrast-enhanced MRI (DCE-MRI) is widely used in the diagnosis and staging of cancer and is emerging as a promising method for monitoring tumour response to treatment. However, DCE-MR imaging techniques are still evolving and methods of image analysis remain variable and non-standard. and range from relative chances in the pattern of enhancement to pharmacokinetic modelling of contrast agent uptake. The combination of results front different institutions is therefore difficult and the sensitivities of different methods, have not been compared. The purpose of this study is to investigate correlation,, between qualitatative and. quantitative methods of analysis for DCE-MR images from breast cancer patients undergoing neo-adjuvant chemotherapy. Fifteen patients underwent DCE-MRI examinations before and after one course of chemotherapy. Changes in the temporal pattern of signal enhancement. the rate and amplitude of enhancement and the volume transfer constant of contrast agent between the blood plasma and the extravascular extracellular space (EES). K-trans, and the EES fractional volume, v(e), were determined. In addition. hole tumour region-of-interest analysis was compared with histogram analysis to investigate the extent of tumour heterogeneity. It was found that changes in the rate of enhancement correlated strongly with changes in K-trans values (Kendall's tau = 0.68. P < 0.001), Furthermore. it as found that the shape of the signal enhancement curve only changed when the K-trans values changed by 50% or more. Median K-trans values determined following histogram analysis of pixel maps of K-trans were approximately equal to those determined by whole tumour re-ion-of-interest analysis. The absolute change in the K-trans values correlated negatively with the pretreatment values. particularly for responding patients. Thus. for higher pre-treatment K-trans values. a greater decrease as observed. Greater changes were observed in the upper extremes of the K-trans histogram than in the median values after one Course of treatment. Copyright (C) 2002 John Wiley Sons. Ltd.