The World Health Organization Classification of Lymphoid Neoplasms
The World Health Organization Classification of Lymphoid Neoplasms
复制标题
DOI：
10.1007/978-1-62703-408-1_1
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Alejandra Carvajal-Cuenca;S. Pileri;E. Campo
中科院分区：
文献类型：
--
作者：
Alejandra Carvajal-Cuenca;S. Pileri;E. Campo
世界卫生组织(世卫组织)于2008年更新的淋巴肿瘤分类代表了全世界对淋巴瘤诊断的共识，并基于两个主要原则：根据肿瘤的细胞谱系及其前体细胞或成熟细胞的来源对肿瘤进行分层，以及对临床上相关的不重叠的不同疾病的定义。这些疾病的鉴定是基于形态学、免疫表型、遗传、分子和临床特征的组合。除了定义明确的实体外，该分类还涉及尚未解决的问题，例如临时实体对应于在发表时没有足够证据支持其被确认为不同疾病的类别，以及大B细胞淋巴瘤与Burkitt或Hodgkin淋巴瘤之间特征重叠的边界类别。
The World Health Organization (WHO) classification of the lymphoid neoplasms updated in 2008 represents a worldwide consensus on lymphoma diagnosis and is based in two major principles: the stratification of neoplasms according to their cell lineage and their derivation of precursor or mature cells and the definition of non-overlapping distinct diseases that are clinically relevant. The identification of these diseases is based on a combination of morphology, immunophenotype, genetic, molecular, and clinical features. In addition to well-defined entities, the classification addresses open issues, such as provisional entities that correspond to categories for which there were insufficient evidence to support its recognition as distinct diseases at the time of publication and borderline categories with overlapping features between large B-cell lymphomas and Burkitt or Hodgkin lymphoma.