Iron stores in man in relation to diet and iron requirements
Iron stores in man in relation to diet and iron requirements
复制标题
DOI：
10.1038/sj.ejcn.1600623
复制
发表时间：
1998-09-01
影响因子：
4.7
通讯作者：
Garby, L
中科院分区：
文献类型：
--
作者：
Hallberg, L;Hulthen, L;Garby, L
目的：计算人体铁储存量及其与铁需求量、膳食铁摄入量和生物利用度相关的变化率。方法：新建立的全膳食铁吸收量与血清铁蛋白 (SF) 之间以及 SF 与铁储存量之间的关系，可以计算不同条件（饮食、损失）下静态吸收量等于损失时储存的铁量。还可以计算商店的增长率。所有计算均基于观察结果，不需要模型假设。结果：目前的铁储存计算与之前观察到的放血值一致。膳食铁的摄入量和生物利用度以及铁需求的差异对储存的铁量有显着影响。研究人员对多种饮食进行了研究，从早期人类典型的假设高肉饮食到发展中国家的饮食。给出了将 SF 转换为铁储备的新方程。对不同条件下商店增长率的分析表明，第一年铁店数量从零开始快速增长（达到最终数量的80%左右），随后2-3年增长速度要慢得多。铁储存的变化率存在明显的惯性，铁储存越接近静止状态，这种惯性越明显，因此很难使用 SF 来估计铁充足受试者铁吸收的短期变化。结论：具有良好生物利用度的现实西式饮食可以满足大多数女性的铁需求，并可以在哺乳期间恢复铁储存。因此，西方女性经期缺铁的高发生率主要与当前饮食中铁的生物利用度进一步降低有关。目前的分析还表明，即使饮食中强化了铁并且即使肉类摄入量很高，也可以有效控制铁的吸收，防止其他健康受试者发生铁超负荷。
Objective: To calculate iron stores in man and their rates of changes in relation to iron requirements and dietary iron intake and bioavailability.Method: Newly established relationships between iron absorption from whole diets and serum ferritin (SF) and between SF and iron stores allow calculations of amounts of stored iron under different conditions (diets, losses) at stationary states when absorption equals losses. Rate of growth of stores can also be calculated. All calculations are based on observations and require no model assumptions.Results: Present calculations of iron stores agree with previously observed phlebotomy values. Differences in intake and bioavailability of dietary iron and in iron requirements had marked effects on amounts of stored iron. A wide range of diets was studied, from a hypothetical high-meat diet typical for early man to diets in developing countries. A new equation is given for the Translation of SF into iron stores. Analyses of growth rate of stores under different conditions showed a fast growth from zero iron stores during the first year (reaching about 80% of final amounts) followed by a much slower rate for 2-3 y. A marked inertia was seen in rate of changes in iron stores that was more marked the closer stores were to their stationary states making it difficult to use SF to estimate short term changes in iron absorption in iron replete subjects.Conclusions: Realistic Western-type diets with good bioavailability can cover iron requirements in most women and can restitute iron stores during lactation. The high prevalence of iron deficiency in menstruating Western women is thus mainly related to a further low bioavailability of iron in present diets. Present analyses also demonstrated an effective control of iron absorption preventing development of iron overload in otherwise healthy subjects even if the diet is fortified with iron and even if meat intake is high.