Study on the hydrolytic degradation of poly(α, β-malic acid) by direct polycondensation
Study on the hydrolytic degradation of poly(α, β-malic acid) by direct polycondensation
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DOI：
10.1016/j.msec.2004.08.029
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发表时间：
2004-12
期刊：
影响因子：
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通讯作者：
T. Kajiyama;Hisatoshi Kobayashi;T. Taguchi;Y. Komatsu;K. Kataoka;J. Tanaka
中科院分区：
文献类型：
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作者：
T. Kajiyama;Hisatoshi Kobayashi;T. Taguchi;Y. Komatsu;K. Kataoka;J. Tanaka
合成的可生物降解聚合物如聚（α-羟基酸）的开发在构建医疗器械（包括支架和缝合线）中至关重要，并且在生物医学中引起了越来越大的兴趣。我们报道了α，β-PMA作为一种可生物降解、可生物吸收的水溶性聚合物的水解。研究了α，β-PMA在pH=5.5、7.0、7.4和8.0的磷酸盐缓冲溶液中的水解。10天后，大部分α，β-PMA的主链酯基已分解。本研究所建立的α，β-PMA的理化性质，有望促进不同分子量的α，β-PMA的制备，这可能在生物材料中具有潜在的应用价值。
The development of synthetic biodegradable polymers such as poly(α-hydroxy acid) is vital in constructing medical devices, including scaffolds and sutures, and has attracted growing interest in biomedicine. We report the hydrolysis of α,β-PMA as a biodegradable, bioabsorbable water-soluble polymer. α,β-PMA hydrolysis was studied in phosphate buffer solutions of pH=5.5, 7.0, 7.4, and 8.0. After 10 days, most main chain ester units of α,β-PMAs had decomposed. The physicochemical properties of α,β-PMA established here are expected to facilitate the production of α,β-PMA of different molecular weights, which may have potential usefulness in biomaterials.