Haploidentical Bone Marrow Transplantation With Clofarabine and Busulfan Conditioning for a Child With Multiple Recurrent Acute Lymphoblastic Leukemia.
Haploidentical Bone Marrow Transplantation With Clofarabine and Busulfan Conditioning for a Child With Multiple Recurrent Acute Lymphoblastic Leukemia.
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使用氯法拉滨和白消安调理的单倍相合骨髓移植治疗患有多发性复发性急性淋巴细胞白血病的儿童。
DOI：
10.1097/mph.0000000000000454
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
et al.
中科院分区：
文献类型：
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作者：
Aoki Y;Miyawaki R;Imai K;et al.
急性淋巴细胞白血病（ALL）患儿的预后近年来有所改善，但对于那些多次复发的患者来说，由于高耐药性和大量预处理病史可能导致身体损伤，预后并没有改善。我们描述的情况下，一个11岁的男孩第三次复发的ALL和2异体骨髓移植的历史。他成功地接受了氯法拉滨联合化疗，并在单倍体骨髓移植后16个月获得了第四次缓解，治疗方案为氯法拉滨和布苏凡。氯法拉滨/布磺胺调节可能是多发性复发性ALL患儿的首选，值得进一步研究。
Outcome of children with acute lymphoblastic leukemia (ALL) has improved over the years, but not for those with multiple recurrences because of high therapy resistance and heavily pretreated history that potentially cause physical damages. We describe the case of an 11-year-old boy with a third relapse of ALL and a history of 2 allogeneic bone marrow transplantations. He was successfully treated with clofarabine combination chemotherapy and achieved a fourth remission at 16 months following haploidentical bone marrow transplantation with conditioning regimen of clofarabine and busulfan. Clofarabine/busulfan conditioning might be a preferable option for children with multiple recurrent ALL, and warrants further investigation.