Genetic susceptibility to infectious diseases: big is beautiful, but will bigger be even better?
Genetic susceptibility to infectious diseases: big is beautiful, but will bigger be even better?
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DOI：
10.1016/s1473-3099(06)70601-6
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发表时间：
2006-10
影响因子：
56.3
通讯作者：
Blackwell, Jenefer M.
中科院分区：
文献类型：
--
作者：
Burgner, David;Jamieson, Sarra E.;Blackwell, Jenefer M.
遗传流行病学，包括双胞胎研究，提供了强有力的证据表明，人类群体中的遗传变异有助于对传染病的易感性。试图确定这种易感性的基因和机制的研究的主要局限性之一是样本量小导致的功效不足。随着新技术的发展，人类基因组信息的迅速增长，HapMap项目和人类遗传多样性，我们正处于复杂疾病遗传学研究的新时代。这篇综述重新审视了支持遗传学在传染病易感性中的作用的流行病学证据，研究了迄今为止有限的成就，并讨论了目前在方法和技术方面的进展，这些进展可能会导致未来的翻译数据。
Genetic epidemiology, including twin studies, provides robust evidence that genetic variation in human populations contributes to susceptibility to infectious disease. One of the major limitations of studies that attempt to identify the genes and mechanisms that underlie this susceptibility has been lack of power caused by small sample size. With the development of novel technologies, burgeoning information on the human genome, the HapMap project, and human genetic diversity, we are at the beginning of a new era in the study of the genetics of complex diseases. This review looks afresh at the epidemiological evidence that supports a role for genetics in susceptibility to infectious disease, examines the somewhat limited achievements to date, and discusses current advances in methodology and technology that will potentially lead to translational data in the future.