Subplate neuron ablation alters neurotrophin expression and ocular dominance column formation.
Subplate neuron ablation alters neurotrophin expression and ocular dominance column formation.
复制标题
板下神经元消融改变神经营养蛋白表达和眼优势柱形成。
DOI：
10.1073/pnas.96.23.13491
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发表时间：
1999
影响因子：
11.1
通讯作者：
Shatz,CJ
中科院分区：
文献类型：
--
作者：
Lein,ES;Finney,EM;McQuillen,PS;Shatz,CJ
视觉皮层中眼优势柱的形成取决于板下神经元的存在和神经营养因子的内源表达。在这里，我们发现，向视觉皮层提供谷氨酸能输入的亚板神经元的缺失，会导致视觉皮层中缺乏眼优势柱的同一区域中脑源性神经营养因子 mRNA 的反常增加。板下神经元消融也会增加谷氨酸脱羧酶 67 的水平，表明皮质抑制发生了变化。这些观察结果表明，这类特殊的神经元通过调节神经营养素的水平和发育中的皮质回路中的兴奋性来调节活动依赖性竞争。
Ocular dominance column formation in visual cortex depends on both the presence of subplate neurons and the endogenous expression of neurotrophins. Here we show that deletion of subplate neurons, which supply glutamatergic inputs to visual cortex, leads to a paradoxical increase in brain-derived neurotrophic factor mRNA in the same region of visual cortex in which ocular dominance columns are absent. Subplate neuron ablation also increases glutamic acid decarboxylase-67 levels, indicating an alteration in cortical inhibition. These observations imply a role for this special class of neurons in modulating activity-dependent competition by regulating levels of neurotrophins and excitability within a developing cortical circuit.