Cortico-basal ganglia-cortical circuitry in Parkinson's disease reconsidered
Cortico-basal ganglia-cortical circuitry in Parkinson's disease reconsidered
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DOI：
10.1016/j.expneurol.2008.04.001
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发表时间：
2008-07-01
影响因子：
5.3
通讯作者：
Del Tredici, Kelly
中科院分区：
文献类型：
--
作者：
Braak, Heiko;Del Tredici, Kelly
经典的皮质-基底节-皮质回路模型，包括间接和直接通路，被用来解释帕金森病（PD）的运动功能减退现象。该模型经过了改进，但强调基底神经节一侧的方程（多巴胺缺乏背侧纹状体）仍然存在。在这里，基本模型的修订版纳入了已知在PD过程中受到影响的关键非多巴胺能连接，因此，皮质-基底节-皮质回路出现在更大的病理过程的背景下。皮质纹状体投射，皮质丘脑底投射和下脑干核团的中心作用被强调。(C)2008年爱思唯尔公司All rights reserved.
The classical model of the cortico-basal ganglia-cortical circuit, with its indirect and direct pathways, was developed to explain the phenomenon of hypokinesia in Parkinson's disease (PD). The model has undergone refinement, but the emphasis on the basal ganglia side of the equation (dopamine deficiency in the dorsal striatum) remains. Here, a revised version of the basic model incorporates key non-dopaminergic connectivities known to become affected in the course of PD and, thus, the cortico-basal ganglia-cortical circuit appears within the context of the larger pathological process. The central roles of the corticostriatal projection, corticosubthalamic projection, and lower brainstem nuclei are emphasized. (C) 2008 Elsevier Inc. All rights reserved.