Differentiation and transdifferentiation potentials of cancer stem cells.
Differentiation and transdifferentiation potentials of cancer stem cells.
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癌症干细胞的分化和转分化潜力
DOI：
10.18632/oncotarget.6098
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发表时间：
2015-11-24
期刊：
影响因子：
--
通讯作者：
Ouyang G
中科院分区：
文献类型：
--
作者：
Huang Z;Wu T;Liu AY;Ouyang G
肿瘤细胞在肿瘤发生和发展过程中积极参与构建自身的微环境。肿瘤微环境包含多种类型的基质细胞，其与细胞外基质以及局部和全身因素一起协同作用以促进肿瘤的发生和进展。肿瘤细胞及其间质区室获得许多遗传和/或表观遗传改变以促进肿瘤生长和转移。肿瘤干细胞（CSC）的概念已被广泛应用于解释肿瘤的发生、生长、转移、休眠和复发。CSC具有分化能力以产生与其正常干细胞对应物相似的原始谱系细胞。有趣的是，最近的证据表明，CSC也有可能转分化成血管内皮细胞和周细胞，表明CSC可以转分化成其他谱系细胞，以促进肿瘤生长和转移，在某些组织环境中，而不是只从局部或远处组织招募基质细胞。尽管CSC转分化为肿瘤基质细胞提供了一个新的维度来解释肿瘤的异质性，但CSC转分化的许多方面仍然难以捉摸。本文就肿瘤干细胞的多向分化和转分化潜能及其对肿瘤异质性和肿瘤微环境的影响作一综述。
Tumor cells actively contribute to constructing their own microenvironment during tumorigenesis and tumor progression. The tumor microenvironment contains multiple types of stromal cells that work together with the extracellular matrix and local and systemic factors to coordinately contribute to tumor initiation and progression. Tumor cells and their stromal compartments acquire many genetic and/or epigenetic alternations to facilitate tumor growth and metastasis. The cancer stem cell (CSC) concept has been widely applied to interpreting tumor initiation, growth, metastasis, dormancy and relapse. CSCs have differentiation abilities to generate the original lineage cells that are similar to their normal stem cell counterparts. Interestingly, recent evidence demonstrates that CSCs also have the potential to transdifferentiate into vascular endothelial cells and pericytes, indicating that CSCs can transdifferentiate into other lineage cells for promoting tumor growth and metastasis in some tissue contexts instead of only recruiting stromal cells from local or distant tissues. Although the transdifferentiation of CSCs into tumor stromal cells provides a new dimension that explains tumor heterogeneity, many aspects of CSC transdifferentiation remain elusive. In this review, we summarize the multi-lineage differentiation and transdifferentiation potentials of CSCs as well as discuss their potential contributions to tumor heterogeneity and tumor microenvironment in tumor progression.