Involvement of sialic acid on endothelial cells in organ-specific lymphocyte recirculation.
Involvement of sialic acid on endothelial cells in organ-specific lymphocyte recirculation.
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唾液酸参与内皮细胞器官特异性淋巴细胞再循环。
DOI：
10.1126/science.4001928
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Stoolman,LM
中科院分区：
文献类型：
--
作者：
Rosen,SD;Singer,MS;Yednock,TA;Stoolman,LM
在淋巴器官（淋巴结和派尔集合淋巴结）的冷冻切片上孵育的小鼠淋巴细胞特异性粘附于高内皮微静脉（HEV）的内皮，当再循环淋巴细胞从血液迁移到淋巴器官的实质中时，再循环淋巴细胞附着于该血管。用唾液酸酶处理切片消除了淋巴细胞与外周淋巴结HEV的结合，对与派尔集合淋巴结HEV的结合没有影响，对肠系膜淋巴结HEV有中间影响。这些结果表明，内皮细胞上的唾液酸可能是淋巴细胞附着的器官特异性识别决定因素。
Mouse lymphocytes incubated on cryostat-cut sections of lymphoid organs (lymph nodes and Peyer's patches) specifically adhere to the endothelium of high endothelial venules (HEV), the specialized blood vessels to which recirculating lymphocytes attach as they migrate from the blood into the parenchyma of the lymphoid organs. Treatment of sections with sialidase eliminated the binding of lymphocytes to peripheral lymph node HEV, had no effect on binding to Peyer's patch HEV, and had an intermediate effect on mesenteric lymph node HEV. These results suggest that sialic acid on endothelial cells may be an organ-specific recognition determinant for lymphocyte attachment.