Quantitative trait locus analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels in the (SM/J x A/J)F2 mice
Quantitative trait locus analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels in the (SM/J x A/J)F2 mice
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DOI：
10.1538/expanim.52.37
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发表时间：
2003-01-01
影响因子：
2.4
通讯作者：
Namikawa, T
中科院分区：
文献类型：
--
作者：
Anunciado, RVP;Nishimura, M;Namikawa, T
对321只SM/J和A/J小鼠的F-2子代进行了10周龄时血清胰岛素、甘油三酯、总胆固醇和磷脂水平的数量性状基因座（QTL）分析。区间作图共检测到22个影响这4个性状的QTL，其中胰岛素QTL 2个，位于第6、8号染色体;甘油三酯QTL 6个，位于第4、8、9、11、12、19号染色体;总胆固醇QTL 6个，位于第1、3、4、14、17、19号染色体;磷脂QTL 8个，位于第2、3、4、6、8、10、19号染色体。性别影响8个暗示性QTL的表达。总胆固醇QTL位于第4、14和17染色体上，甘油三酯QTL位于第9染色体上，磷脂QTL位于第4染色体上，是雌性特有的。第2、6染色体上的磷脂QTL和第8染色体上的胰岛素QTL为雄性特有。此外，还鉴定了参与部分性状调控的常见QTL。Chr 4上的雌性特异性QTL似乎参与了总胆固醇和磷脂水平的调节。第8染色体上的QTL影响胰岛素和磷脂水平，而第19染色体上的QTL是共同的三个脂质参数。
Quantitative trait locus (QTL) analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels at 10 weeks of age was performed in 321 F-2 offspring from SM/J and A/J mice. Interval mapping revealed a total of 22 suggestive QTLs affecting the four traits: two insulin QTLs on Chromosomes (Chrs) 6 and 8; six triglyceride QTLs on Chrs 4, 8, 9, 11, 12 and 19; six total-cholesterol QTLs on Chrs 1, 3, 4, 14, 17 and 19; and eight phospholipid QTLs on Chrs 2, 3, 4, 6, 8, 10 and 19. Gender influenced the expression of eight of the suggestive QTLs. The total-cholesterol QTLs on Chrs 4, 14 and 17, the triglyceride QTL on Chr 9 and the phospholipid QTL on Chr 4 were specific to females. The phospholipid QTLs on Chrs 2 and 6 and the insulin QTL on Chr 8 were specific to males. In addition, common QTLs involved in the regulation of some of the traits were identified. The female-specific QTL on Chr 4 appeared to be involved in the regulation of total cholesterol and phospholipid levels. The QTL on Chr 8 affected insulin and phospholipid levels, whereas the Chr 19 QTL was common to the three lipid parameters.