Recalculation of dose for each fraction of treatment on TomoTherapy
Recalculation of dose for each fraction of treatment on TomoTherapy
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DOI：
10.1259/bjr.20150770
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发表时间：
2016-01-01
影响因子：
2.6
通讯作者：
Burnet, Neil G.
中科院分区：
文献类型：
--
作者：
Thomas, Simon J.;Romanchikova, Marina;Burnet, Neil G.
目标：VoxTox研究将递送剂量与毒性联系起来，对于近2000名患者，需要重新计算每个患者通常20-37个分数。这需要一个非交互式界面，允许多台计算机进行批量计算。方法：数据从TomoTherapy（R）存档中提取，并使用计算任务管理系统GANGA进行处理。使用每日兆伏（MV）CT图像计算放射治疗每个部分的剂量。计算的剂量立方体被保存为医学RTDOSE对象中的数字成像和通信，然后可以由计算剂量体积直方图或剂量表面图的实用程序读取。直肠划定每天MV图像上使用的Chan-Vese algorithm.Results的实现：在一个集群的117个中央处理器，剂量立方体的所有部分的151例患者需要12天来计算。在151名患者的所有切片和切片上勾画直肠轮廓需要7小时。我们还介绍了TomoTherapy MV图像的Hounsfield单位（HU）校准的结果，在8年的时间内测量，显示HU校准随着时间的推移变得变化较小，在2011年之后没有观察到大的变化。结论：我们已经开发了一个系统，用于TomoTherapy剂量分布的自动剂量重新计算。这不会占用临床所需的计划系统，而是可以在一组独立的机器上运行，无需用户干预即可重新计算输送剂量。知识的进步：使用任务管理系统自动化剂量计算和概述，可以将工作扩展到大型研究所需的水平。
Objective: The VoxTox study, linking delivered dose to toxicity requires recalculation of typically 20-37 fractions per patient, for nearly 2000 patients. This requires a non-interactive interface permitting batch calculation with multiple computers.Methods: Data are extracted from the TomoTherapy (R) archive and processed using the computational task-management system GANGA. Doses are calculated for each fraction of radiotherapy using the daily megavoltage (MV) CT images. The calculated dose cube is saved as a digital imaging and communications in medicine RTDOSE object, which can then be read by utilities that calculate dose-volume histograms or dose surface maps. The rectum is delineated on daily MV images using an implementation of the Chan-Vese algorithm.Results: On a cluster of up to 117 central processing units, dose cubes for all fractions of 151 patients took 12 days to calculate. Outlining the rectum on all slices and fractions on 151 patients took 7 h. We also present results of the Hounsfield unit (HU) calibration of TomoTherapy MV images, measured over an 8-year period, showing that the HU calibration has become less variable over time, with no large changes observed after 2011.Conclusion: We have developed a system for automatic dose recalculation of TomoTherapy dose distributions. This does not tie up the clinically needed planning system but can be run on a cluster of independent machines, enabling recalculation of delivered dose without user intervention.Advances in knowledge: The use of a task management system for automation of dose calculation and outlining enables work to be scaled up to the level required for large studies.