Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in an aging and dementia cohort.
Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in an aging and dementia cohort.
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DOI：
10.1016/j.sleep.2010.12.009
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发表时间：
2011-05
期刊：
影响因子：
4.8
通讯作者：
Silber, Michael H.
中科院分区：
文献类型：
--
作者：
Boeve, Bradley F.;Molano, Jennifer R.;Ferman, Tanis J.;Smith, Glenn E.;Lin, Siong-Chi;Bieniek, Kevin;Haidar, Wael;Tippmann-Peikert, Maja;Knopman, David S.;Graff-Radford, Neill R.;Lucas, John A.;Petersen, Ronald C.;Silber, Michael H.
为了验证一份关于老年和痴呆症队列参与者中REM睡眠行为障碍(RBD)的问卷。RBD是一种睡眠异常症，可在其他神经学正常的成年人身上发生，也可在患有神经退行性疾病的人中发展。RBD的确诊需要多导睡眠图(PSG)。为了临床和研究目的，一个简单的RBD筛查措施是可取的。我们之前开发了梅奥睡眠问卷(MSQ)，这是一种16项测量工具，用于筛查RBD和其他睡眠障碍的存在。我们通过比较患者床伴的反应和PSG的结果来评估MSQ的有效性。2008年1月1日至2008年7月在罗切斯特梅奥诊所和杰克逊维尔梅奥诊所的梅奥阿尔茨海默病研究中心招募的所有也接受过PSG的受试者都是这项分析的重点。研究样本包括176名受试者[150名男性；平均年龄71岁(范围39-90岁)]，临床诊断如下：正常(n=8)、轻度认知障碍(n=44)、阿尔茨海默病(n=23)、路易体痴呆(n=74)以及其他痴呆症和/或帕金森综合征(n=27)。以反复做梦行为为核心问题，诊断RBD的灵敏度(SN)为98%，特异度(SP)为74%。另外四个关于RBD的子题和一个关于阻塞性睡眠呼吸暂停的子题的回答提高了特异性。这些数据表明，在认知障碍和/或帕金森综合征的老年受试者中，MSQ具有足够的SN和SP来诊断RBD。这一量表在其他患者群体中的应用还需要进一步研究。
To validate a questionnaire focused on REM sleep behavior disorder (RBD) among participants in an aging and dementia cohort. RBD is a parasomnia that can develop in otherwise neurologically-normal adults as well as in those with a neurodegenerative disease. Confirmation of RBD requires polysomnography (PSG). A simple screening measure for RBD would be desirable for clinical and research purposes. We had previously developed the Mayo Sleep Questionnaire (MSQ), a 16 item measure, to screen for the presence of RBD and other sleep disorders. We assessed the validity of the MSQ by comparing the responses of patients’ bed partners with the findings on PSG. All subjects recruited in the Mayo Alzheimer’s Disease Research Center at Mayo Clinic Rochester and Mayo Clinic Jacksonville from 1/00 to 7/08 who had also undergone a PSG were the focus of this analysis. The study sample was comprised of 176 subjects [150 male; median age 71 years (range 39–90)], with the following clinical diagnoses: normal (n=8), mild cognitive impairment (n=44), Alzheimer’s disease (n=23), dementia with Lewy bodies (n=74), as well as other dementia and/or parkinsonian syndromes (n=27). The core question on recurrent dream enactment behavior yielded a sensitivity (SN) of 98% and specificity (SP) of 74% for the diagnosis of RBD. The profile of responses on four additional subquestions on RBD and one on obstructive sleep apnea improved specificity. These data suggest that among aged subjects with cognitive impairment and/or parkinsonism, the MSQ has adequate SN and SP for the diagnosis of RBD. The utility of this scale in other patient populations will require further study.
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影响因子：
9.9
作者：
Boeve, B;Silber, MH;Mahowald, MW
通讯作者：
Mahowald, MW
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