Mapping a putative pyruvoyl decarboxylase active site to human cytomegalovirus open reading frame UL77.
Mapping a putative pyruvoyl decarboxylase active site to human cytomegalovirus open reading frame UL77.
复制标题
将假定的丙酮酰脱羧酶活性位点映射到人巨细胞病毒开放阅读框 UL77。
DOI：
10.1006/bbrc.1993.1951
复制
发表时间：
1993
影响因子：
3.1
通讯作者：
Yoakum,GH
中科院分区：
文献类型：
--
作者：
Yoakum,GH
Human cytomegalovirus is present as an apparently innocuous infection among a large proportion of the adult population that causes serious disease when congenitally transferred (1). Human cytomegalovirus disease may become life threatening when found as an infection of immunocompromised transplant and AIDS patients (1,2). We now map a putative pyruvoyl decarboxylase enzyme prosthetic group, known to be essential to the active site of this class of enzymes, to Human cytomegalovirus open reading frame UL77. The significance of finding a putative pyruvoyl decarboxylase enzyme prosthetic group among human cytomegalovirus open reading frame codons is p = 0.001. The UL77 polypeptide was aligned with human, yeast and bacterial S-AdoMet decarboxylase enzymes. Alignment of UL77 and S-AdoMet decarboxylase enzymes indicates that UL77 may contain a similar activity.
