Vagus nerve stimulation: A new tool for brain research and therapy
Vagus nerve stimulation: A new tool for brain research and therapy
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DOI：
10.1016/s0006-3223(99)00308-x
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发表时间：
2000-02-15
影响因子：
10.6
通讯作者：
Ballenger, JC
中科院分区：
文献类型：
--
作者：
George, MS;Sackeim, HA;Ballenger, JC
生物精神病学在利用躯体疗法治疗神经精神疾病以及了解大脑功能方面有着悠久的历史！这些方法包括神经外科手术、电休克疗法，以及最近的经颅磁刺激。14年前，研究人员发现对迷走神经进行间歇性电刺激会抑制神经过程，这能够改变大脑的电活动并终止狗的癫痫发作。从那时起，全球约有6000人因难治性癫痫接受了迷走神经刺激治疗。我们回顾了迷走神经的神经生物学和解剖学，并对迷走神经刺激技术进行了概述。我们还描述了迷走神经刺激作为一种神经科学研究工具以及一种可能的精神疾病治疗方法的安全性和潜在用途。迷走神经刺激似乎是一种有前途的新型躯体干预措施，它可能增进我们对大脑功能的理解，并在神经精神疾病的治疗中具有前景。《生物精神病学》2000年；47卷：287 - 295页（C）2000年生物精神病学学会。
Biological psychiatry has a long history! of using somatic therapies to tl ent neuropsychiatric illnesses and to understand brain function, These methods have included neurosurgery, electroconvulsive therapy, and most recently, transcranial magnetic stimulation, Fourteen years ago researchers discovered that intermittent electrical stimulation of the vagus nerve produces inhibition of neural processes, which can alter brain electrical activity and terminate seizures in dogs. Since then, approximately 6000 people worldwide have received vagus nerve stimulation for treatment-resistant epilepsy. We review the neurobiology, and anatomy of the vagus nerve and provide an overview of the vagus nerve stimulation technique. We also describe the safety and potential utility of vagus nerve stimulation as a neuroscience research tool and as a putative treatment for psychiatric conditions. Vagus nerve stimulation appears to be a promising new somatic intervention that may improve our understanding of brain function and has promise in the treatment of neuropsychiatric disorders. Biol Psychiatry 2000;47:287-295 (C) 2000 Society, of Biological Psychiatry.