CD151 forms a functional complex with c-Met in human salivary gland cancer cells.
CD151 forms a functional complex with c-Met in human salivary gland cancer cells.
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DOI：
10.1016/j.bbrc.2005.08.106
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发表时间：
2005-10
影响因子：
3.1
通讯作者：
S. Kłosek;K. Nakashiro;S. Hara;S. Shintani;H. Hasegawa;H. Hamakawa
中科院分区：
文献类型：
--
作者：
S. Kłosek;K. Nakashiro;S. Hara;S. Shintani;H. Hasegawa;H. Hamakawa
在这项研究中，我们试图阐明CD151在人唾液腺癌细胞中的表达和功能。CD151在Acc2和AccM细胞中表达，但在正常组织和原代培养的人唾液腺上皮细胞中没有表达。CD151已被发现在c-Met/肝细胞生长因子（HGF）受体与整合素α3/α6之间形成复合物的分子连接体中起作用。敲低CD151或整合素α3/α6的表达几乎完全消除了hgf刺激的细胞生长和迁移。相反，在Acc2细胞中强制表达CD151导致hgf依赖性生物学效应的增加。这些结果表明，CD151与c-Met和整合素α3/α6形成结构和功能复合物，并通过过度激活HGF/c-Met信号通路发挥其致癌功能。
In this study, we have attempted to elucidate the expression and function of CD151 in human salivary gland cancer cells. CD151 expression was detected in Acc2 and AccM cells, but not in normal tissues and primary cultured epithelial cells derived from human salivary gland. CD151 has been found to function as a molecular linker in the formation of complexes between c-Met/hepatocyte growth factor (HGF) receptor and integrin α3/α6. Knockdown of CD151 or integrin α3/α6 expression almost completely abrogated HGF-stimulated cell growth and migration. In contrast, forced expression of CD151 in Acc2 cells resulted in the increase of the HGF-dependent biological effects. These results suggest that CD151 forms a structural and functional complex with c-Met and integrin α3/α6, and exerts its oncogenic functions through excessive activation of the HGF/c-Met signalling pathway.