Increased ventral striatal monoaminergic innervation in Tourette syndrome
Increased ventral striatal monoaminergic innervation in Tourette syndrome
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DOI：
10.1212/01.wnl.0000076181.39162.fc
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发表时间：
2003-08-12
期刊：
影响因子：
9.9
通讯作者：
Frey, KA
中科院分区：
文献类型：
--
作者：
Albin, RL;Koeppe, RA;Frey, KA
背景：过度的纹状体多巴胺能神经支配被认为是抽动秽语综合征（TS）的基础。先前的成像和尸检研究产生了相互矛盾的数据。研究方法：作者使用PET和2型囊泡单胺转运体配体[C-11]二氢丁苯那嗪（DTBZ）定量TS患者（n = 19）和对照受试者（n = 27）的纹状体单胺能神经支配。房室模型用于确定DTBZ连续输注期间血液至脑配体转运（K-1）和组织至血浆分布体积（配体结合的测量）。使用预定义的感兴趣区域和逐体素的基础上，将TS数据与对照数据进行比较。结果如下：TS患者和对照组背侧纹状体的配体结合或配体转运无显著差异。通过逐体素分析，右腹侧纹状体中DTBZ结合增加。结论：以前报道的TS患者和对照组之间的背侧纹状体多巴胺末端标记物的差异可能反映了药物诱导的调节末端标记物的表达或纹状体多巴胺能突触功能的内在差异的结果。增加右腹侧纹状体DTBZ结合表明，异常腹侧纹状体多巴胺能神经支配可能是抽搐的基础。
Background: Excessive striatal dopaminergic innervation is suggested to underlie Tourette syndrome (TS). Prior imaging and postmortem studies yield conflicting data. Methods: The authors used PET with the type 2 vesicular monoamine transporter ligand [C-11] dihydrotetrabenazine (DTBZ) to quantify striatal monoaminergic innervation in patients with TS (n = 19) and control subjects (n = 27). Compartmental modeling was used to determine blood to brain ligand transport (K-1) and tissue to plasma distribution volume ( a measure of ligand binding) during continuous infusion of DTBZ. TS data were compared with control data using predefined regions of interest and on a voxel by voxel basis. Results: There were no significant differences in ligand binding or ligand transport between patients with TS and control subjects in the dorsal striatum. With voxel by voxel analysis, there was increased DTBZ binding in the right ventral striatum. Conclusions: Previously reported differences between patients with TS and control subjects in dorsal striatal dopamine terminal markers may reflect medication-induced regulation of terminal marker expression or be the result of intrinsic differences in striatal dopaminergic synaptic function. Increased right ventral striatal DTBZ binding suggests that abnormal ventral striatal dopaminergic innervation may underlie tics.