A MONOCLONAL-ANTIBODY THAT RECOGNIZES A PHOSPHORYLATED EPITOPE IN ALZHEIMER NEUROFIBRILLARY TANGLES, NEUROFILAMENTS AND TAU PROTEINS IMMUNOSTAINS GRANULOVACUOLAR DEGENERATION
A MONOCLONAL-ANTIBODY THAT RECOGNIZES A PHOSPHORYLATED EPITOPE IN ALZHEIMER NEUROFIBRILLARY TANGLES, NEUROFILAMENTS AND TAU PROTEINS IMMUNOSTAINS GRANULOVACUOLAR DEGENERATION
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DOI：
10.1007/bf00686619
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发表时间：
1987-01-01
影响因子：
12.7
通讯作者：
YEN, SH
中科院分区：
文献类型：
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作者：
DICKSON, DW;KSIEZAKREDING, H;YEN, SH
针对阿尔茨海默氏病脑提取物产生的单克隆抗体识别高分子量神经丝蛋白和tau蛋白中的磷酸化表位，也免疫染色阿尔茨海默氏病神经元缠结、老年斑中的神经突和颗粒空泡变性。这一结果表明，颗粒空泡变性可能含有磷酸化蛋白，这可能是由于磷酸化核周蛋白的自噬，这似乎在阿尔茨海默病中增加。
A monoclonal antibody, raised against extracts from Alzheimer brain, that recognizes a phosphorylated epitope in high molecular weight neurofilament proteins and tau proteins also immunostains Alzheimer neurofibrillary tangles, neurites in senile plaques and granulovacuolar degeneration. This result suggests that granulovacuolar degeneration may contain phosphorylated proteins, possibly due to autophagy of phosphorylated perikaryal proteins that appear to be increased in Alzheimer''s disease.