Noradrenergic modulation of cognitive flexibility in problem solving
Noradrenergic modulation of cognitive flexibility in problem solving
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DOI：
10.1097/00001756-199909090-00012
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发表时间：
1999-09-09
期刊：
影响因子：
1.7
通讯作者：
Heilman, KM
中科院分区：
文献类型：
--
作者：
Beversdorf, DQ;Hughes, JD;Heilman, KM
压力会导致创造力测试中的表现受损。阻断肾上腺素能受体的药物可以改善患有考试焦虑的患者的考试表现。此外，儿茶酚胺前体（左旋多巴）降低了语义网络的灵活性。本研究探讨了去甲肾上腺素能系统调节对问题解决认知灵活性的影响。18名正常受试者在服用了普萘洛尔、安慰剂和麻黄碱后45分钟接受了三个问题解决任务（数字序列、形状操作和字谜）。在最依赖于认知灵活性的任务（字谜）上，最有能力解决这些问题的受试者在服用心得安后比服用麻黄碱后明显缩短了解决时间（对数分数）。这表明去甲肾上腺素能系统对解决问题的认知灵活性有调节作用。(C) 1999 Lippincott Williams & Wilkins。
STRESS causes impaired performance on tests of creativity. Drugs that block beta-adrenergic receptors improve test performance in patients with test anxiety. Furthermore, catecholamine precursors (L-DOPA) reduce the flexibility of semantic networks. Our study investigated the effect of noradrenergic system modulation on cognitive flexibility in problem solving. Eighteen normal subjects undertook three problem solving tasks (number series, shape manipulation and anagrams) 45 min after propranolol, placebo and ephedrine. On the task that appeared to rely most heavily on cognitive flexibility (anagrams), subjects who were most able to serve these problems demonstrated significantly shorter solution times (logarithmic scores) after propranolol than after ephedrine. This suggested that the noradrenergic system exerts a modulatory effect on cognitive flexibility in problem solving. (C) 1999 Lippincott Williams & Wilkins.