Effects of Neonicotinoid Pesticide Exposure on Human Health: A Systematic Review.
Effects of Neonicotinoid Pesticide Exposure on Human Health: A Systematic Review.
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DOI：
10.1289/ehp515
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发表时间：
2017-02
影响因子：
10.4
通讯作者：
Perry MJ
中科院分区：
文献类型：
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作者：
Cimino AM;Boyles AL;Thayer KA;Perry MJ
许多研究已经确定了环境中可检测到的新烟碱(Neonics)水平，霓虹灯对包括哺乳动物在内的许多物种的不利影响，以及人类暴露于霓虹灯的途径，但对霓虹灯对人类健康的影响知之甚少。在这项系统的综述中，我们试图确定关于霓虹灯对健康影响的人群研究。使用PubMed、Scope us和Web of Science数据库对2005至2015年间发表的英文研究进行检索。对评估的健康结果的类型没有任何限制。使用国家毒理学计划的健康评估和翻译办公室制定的指南来评估偏倚的风险。确定了八项研究，调查暴露在霓虹灯下对人类健康的影响。四项检查了急性暴露：三项霓虹灯中毒研究报告了两人死亡(n=1280例)，一项针对19名林业工人的职业暴露研究报告了没有不良影响。四项普通人群研究报告了慢性霓虹灯暴露与不良的发育或神经后果之间的关系，包括法洛四联症(AOR 2.4，95%CI：1.1，5.4)、无脑症(AOR 2.9，95%CI：1.0，8.2)、自闭症谱系障碍[AOR 1.3，95%可信区间：0.78，2.2]，以及包括记忆力丧失和手指震颤在内的症状群(OR 14，95%CI：3.5，57)。报告的优势比是基于暴露组与未暴露组的比较。到目前为止，进行的研究数量有限，与慢性暴露相关的提示性但方法薄弱的发现。鉴于霓虹灯的广泛使用，需要更多的研究来充分了解它们对人类健康的影响。Cimino AM，Boyles AL，Thayer Ka，Perry MJ。2017年。新烟碱类农药暴露对人类健康的影响：一项系统评价。环境健康展望125：155-162；http://dx.doi.org/10.1289/EHP515
Numerous studies have identified detectable levels of neonicotinoids (neonics) in the environment, adverse effects of neonics in many species, including mammals, and pathways through which human exposure to neonics could occur, yet little is known about the human health effects of neonic exposure. In this systematic review, we sought to identify human population studies on the health effects of neonics. Studies published in English between 2005 and 2015 were searched using PubMed, Scopus, and Web of Science databases. No restrictions were placed on the type of health outcome assessed. Risk of bias was assessed using guidance developed by the National Toxicology Program’s Office of Health Assessment and Translation. Eight studies investigating the human health effects of exposure to neonics were identified. Four examined acute exposure: Three neonic poisoning studies reported two fatalities (n = 1,280 cases) and an occupational exposure study of 19 forestry workers reported no adverse effects. Four general population studies reported associations between chronic neonic exposure and adverse developmental or neurological outcomes, including tetralogy of Fallot (AOR 2.4, 95% CI: 1.1, 5.4), anencephaly (AOR 2.9, 95% CI: 1.0, 8.2), autism spectrum disorder [AOR 1.3, 95% credible interval (CrI): 0.78, 2.2], and a symptom cluster including memory loss and finger tremor (OR 14, 95% CI: 3.5, 57). Reported odds ratios were based on exposed compared to unexposed groups. The studies conducted to date were limited in number with suggestive but methodologically weak findings related to chronic exposure. Given the wide-scale use of neonics, more studies are needed to fully understand their effects on human health. Cimino AM, Boyles AL, Thayer KA, Perry MJ. 2017. Effects of neonicotinoid pesticide exposure on human health: a systematic review. Environ Health Perspect 125:155–162; http://dx.doi.org/10.1289/EHP515