Early versus late MCI: Improved MCI staging using a neuropsychological approach
Early versus late MCI: Improved MCI staging using a neuropsychological approach
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DOI：
10.1016/j.jalz.2018.12.009
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发表时间：
2019-05-01
影响因子：
14
通讯作者：
Bondi, Mark W.
中科院分区：
文献类型：
--
作者：
Edmonds, Emily C.;McDonald, Carrie R.;Bondi, Mark W.
简介：阿尔茨海默病神经影像倡议 (ADNI) 根据单一记忆测试区分“早期”和“晚期”轻度认知障碍 (MCI)。我们将 ADNI 的 MCI 分类与我们的神经心理学方法进行了比较，神经心理学方法更广泛地评估认知能力。方法：336 名 ADNI-2 参与者被分类为“早期”或“晚期”MCI。对神经心理学测试数据进行聚类分析，并根据聚类结果对参与者进行重新分类。对这两种分期方法的进展率、脑脊液生物标志物和皮质厚度概况进行了比较。结果：两种分期方法之间几乎没有对应性。 ADNI 的早期 MCI 组包含很大一部分假阳性诊断错误。重新分类的神经心理学 MCI 组表现出更陡峭的生存曲线和更多异常的生物标志物。 结论：我们的新颖神经心理学方法通过以下方式改善了 MCI 的分期：(1) 在早期症状阶段捕获个体，(2) 最大限度地减少假阳性病例，以及 (3) 沿着疾病轨迹进一步识别晚期 MCI 组。由爱思唯尔公司代表阿尔茨海默病协会出版。
Introduction: The Alzheimer's Disease Neuroimaging Initiative (ADNI) separates "early" and "late" mild cognitive impairment (MCI) based on a single memory test. We compared ADNI's MCI classifications to our neuropsychological approach, which more broadly assesses cognitive abilities.Methods: Three hundred thirty-six ADNI-2 participants were classified as "early" or "late" MCI. Cluster analysis was performed on neuropsychological test data, and participants were reclassified based on cluster results. These two staging approaches were compared on progression rates, cerebrospinal fluid biomarkers, and cortical thickness profiles.Results: There was little correspondence between the two staging methods. ADNI's early MCI group included a large proportion of false-positive diagnostic errors. The reclassified neuropsychological MCI groups showed steeper survival curves and more abnormal biomarkers.Conclusions: Our novel neuropsychological approach improved the staging of MCI by (1) capturing individuals at an early symptomatic stage, (2) minimizing false-positive cases, and (3) identifying a late MCI group further along the disease trajectory. Published by Elsevier Inc. on behalf of the Alzheimer's Association.