Phenolic Alkaloids as a New Class of Antioxidants in Portulaca oleracea
Phenolic Alkaloids as a New Class of Antioxidants in Portulaca oleracea
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DOI：
10.1002/ptr.2742
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发表时间：
2009-07-01
影响因子：
7.2
通讯作者：
Zheng, Yinan
中科院分区：
文献类型：
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作者：
Yang, Zijuan;Liu, Cejia;Zheng, Yinan
三种酚性生物碱的抗氧化活性，以1，1-二苯基-2-苦肼基自由基（DPPH）自由基和过氧化氢诱导的大鼠脑匀浆脂质过氧化反应为指标，测定了马齿苋中分离得到的3种化合物-橄榄素A（OA）、橄榄素B（011）和橄榄素E（OE）的清除活性。这些酚性生物碱清除DPPH自由基的活性低于咖啡酸，但高于抗坏血酸和α-生育酚，其顺序为：OB > OA > OE，OE在防止丙二醛（MDA）形成方面最有效，其EC_（50）值为73.13 μ M，接近咖啡酸的EC_（50）值（72.09 μ M）。研究表明，酚性生物碱是一种新的抗氧化剂。版权所有（C）2009约翰威利父子有限公司
Antioxidant activities of three phenolic alkaloids, i.e., oleracein A (OA), oleracein B (011) and oleracein E (OE), isolated from Portulaca oleracea were determined, based on scavenging activity against 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical and inhibitory effect on hydrogen peroxide-induced lipid peroxidation in rat brain homogenates. The DPPH radical scavenging activities of these phenolic alkaloids were lower than caffeic acid but higher than ascorbic acid and alpha-tocopherol, being in the following order: OB > OA > OE. OE was most potent in preventing formation of malondialdehyde (MDA) with an EC50 value of 73.13 mu M close to that of caffeic acid (72.09 mu M). It was demonstrated that phenolic alkaloids served as a new class of antioxidant agents in this plant. Copyright (C) 2009 John Wiley & Sons, Ltd.