Seroprevalence of Herpes Simplex Virus Types 1 and 2-United States, 1999-2010
Seroprevalence of Herpes Simplex Virus Types 1 and 2-United States, 1999-2010
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DOI：
10.1093/infdis/jit458
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发表时间：
2014-02-01
影响因子：
6.4
通讯作者：
McQuillan, Geraldine M.
中科院分区：
文献类型：
--
作者：
Bradley, Heather;Markowitz, Lauri E.;McQuillan, Geraldine M.
背景资料。单纯疱疹病毒1型和2型(HSV-1和HSV-2)是常见的感染，有严重的后遗症。在工业化国家，HSV-1是生殖器疱疹的一个日益重要的原因。使用来自国家健康和营养检查调查(NHANES)的具有全国代表性的数据，我们检查了美国14至49岁人群中HSV-1和HSV-2的血清阳性率。我们估计了1999-2004年和2005-2010年的血清阳性率，按社会人口学特征和性行为分层。我们还回顾了1976-1980年至2005-2010年间HSV-1和HSV-2的血清阳性率。2005-2010年HSV-1血清阳性率为53.9%，HSV-2血清阳性率为15.7%。从1999-2004年到2005-2010年，HSV-1血清阳性率下降了近7%(P<；.01)，但HSV-2血清阳性率没有显著变化。从1999-2004年到2005-2010年，HSV-1血清阳性率下降最多的是14-19岁的青少年，其中血清阳性率下降了近23%，从39.0%下降到30.1%(P<；.01)。在这个年龄段，从1976-1980年到2005-2010年，HSV-1血清阳性率下降了29%(P<；.01)。越来越多的青少年在首次性行为时缺乏HSV-1抗体。在HSV-2感染没有下降的情况下，生殖器疱疹的流行可能会增加。
Background. Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are common infections with serious sequelae. HSV-1 is an increasingly important cause of genital herpes in industrialized countries.Methods. Using nationally representative data from the National Health and Nutrition Examination Survey (NHANES), we examined HSV-1 and HSV-2 seroprevalence among 14- to 49-year-olds in the United States. We estimated seroprevalence in 1999-2004 and 2005-2010, stratified by sociodemographic characteristics and sexual behaviors. We also reviewed HSV-1 and HSV-2 seroprevalence from 1976-1980 to 2005-2010.Results. In 2005-2010, the seroprevalence of HSV-1 was 53.9%, and the seroprevalence of HSV-2 was 15.7%. From 1999-2004 to 2005-2010, HSV-1 seroprevalence declined by nearly 7% (P < .01), but HSV-2 seroprevalence did not change significantly. The largest decline in HSV-1 seroprevalence from 1999-2004 to 2005-2010 was observed among adolescents aged 14-19 years, among whom seroprevalence declined by nearly 23%, from 39.0% to 30.1% (P < .01). In this age group, HSV-1 seroprevalence declined > 29% from 1976-1980 to 2005-2010 (P < .01).Conclusions. An increasing number of adolescents lack HSV-1 antibodies at sexual debut. In the absence of declines in HSV-2 infections, the prevalence of genital herpes may increase.