Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q
Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q
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DOI：
10.1073/pnas.0335669100
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发表时间：
2003-03-04
影响因子：
11.1
通讯作者：
Weissman, MM
中科院分区：
文献类型：
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作者：
Hamilton, SP;Fyer, AJ;Weissman, MM
大量证据支持恐慌症（PD）有遗传成分。直到最近，通过使用标准表型数据定位PD基因的尝试还没有被证明是成功的。先前的工作表明，存在一种称为惊恐综合征的PD潜在亚型，其特征在于许多医学状况，最明显的是膀胱/肾脏疾病。在目前的研究中，对分离PD和膀胱/肾脏疾病的60个多重家系中的587名个体进行了384个微卫星标记的基因组扫描。使用单位点和多点分析方法，我们发现显着的连锁22号染色体（最大异质性对数的优势得分= 4.11在D22 S445）和13号染色体q（异质性对数的优势得分= 3.57在D13 S793）下的显性遗传模型和广泛的表型定义。多点分析不支持22号染色体上的观察结果。13号染色体的研究结果得到了多点研究结果的证实，并扩展了我们以前在60个家庭中的19个家庭中的研究结果。当使用一种分析方法时，其他几个地区的得分也有所提高，但另一种方法则没有。这些结果表明，染色体13 q上的基因，也可能在染色体22上，影响对多效性综合征的易感性，包括PD，膀胱问题，严重头痛，二尖瓣脱垂和甲状腺疾病。
Substantial evidence supports that there is a genetic component to panic disorder (PD). Until recently, attempts at localizing genes for PD by using standard phenotypic data have not proven successful. Previous work suggests that a potential subtype of PD called the panic syndrome exists, and it is characterized by a number of medical conditions, most notably bladder/renal disorders. In the current study, a genome scan with 384 microsatellite markers was performed on 587 individuals in 60 multiplex pedigrees segregating PD and bladder/kidney conditions. Using both single-locus and multipoint analytic methods, we found significant linkage on chromosome 22 (maximum heterogeneity logarithm of odds score = 4.11 at D22S445) and on chromosome 13q (heterogeneity logarithm of odds score = 3.57 at D13S793) under a dominant-genetic model and a broad phenotypic definition. Multipoint analyses did not support the observation on chromosome 22. The chromosome 13 findings were corroborated by multipoint findings, and extend our previous findings from 19 of the 60 families. Several other regions showed elevated scores by using when one analytic method was used, but not the other. These results suggest that there are genes on chromosome 13q, and possibly on chromosome 22 as well, that influence the susceptibility toward a pleiotropic syndrome that includes PD, bladder problems, severe headaches, mitral valve prolapse, and thyroid conditions.