Event-related beta desynchronization in human subthalamic nucleus correlates with motor performance
Event-related beta desynchronization in human subthalamic nucleus correlates with motor performance
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DOI：
10.1093/brain/awh106
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发表时间：
2004-04-01
期刊：
影响因子：
14.5
通讯作者：
Brown, P
中科院分区：
文献类型：
--
作者：
Kühn, AA;Williams, D;Brown, P
尽管基底神经节在自我产生的运动中起重要作用，但它们在外部节奏的自主运动中的作用尚不清楚。我们记录了8名帕金森病患者在执行警告反应时间任务时丘脑下核区域的局部场电位（LFPs），在该任务中，一个命令提示指示受试者移动或不移动。在“go”试验中，β频段（类似于20 Hz）的LFP活性在运动前下降，发病潜伏期与患者的平均反应时间密切相关。随后是运动后beta能量的增加。相比之下，在“nogo”试验中，与go试验相比，指令信号后的beta功率下降过早终止，并逆转为早期的beta功率增加。当围棋试验减去围棋试验时，这些差异表现为功率增加。在6例患者中，这些相对-功率增加在nogo-go差异试验中的潜伏期短于各自的反应时间。研究结果表明，首先，丘脑下核参与了人类外部节奏自主运动的准备，其次，丘脑下核在β带活动的同步程度可能是运动编程和运动启动是有利还是抑制的重要决定因素。
Although the basal ganglia play an important role in self-generated movement, their involvement in externally paced voluntary movement is less clear. We recorded local field potentials (LFPs) from the region of the subthalamic nuclei of eight patients with Parkinson's disease during the performance of a warned reaction time task in which an imperative cue instructed the subject to move or not to move. In 'go' trials, LFP activity in the beta frequency band (similar to20 Hz) decreased prior to movement, with an onset latency that strongly correlated with mean reaction time across patients. This was followed by a late post-movement increase in beta power. In contrast, in 'nogo' trials the beta power drop following imperative signals was prematurely terminated compared with go trials and reversed into an early beta power increase. These differences were manifest as power increases when go trials were subtracted from nogo trials. In six patients these relative beta power increases in nogo-go difference trials were of shorter latency than the respective reaction time. The findings suggest that, firstly, the subthalamic nucleus is involved in the preparation of externally paced voluntary movements in humans and, secondly, the degree of synchronization of subthalamic nucleus activity in the beta band may be an important determinant of whether motor programming and movement initiation is favoured or suppressed.