Brain-behaviour modes of covariation in healthy and clinically depressed young people
Brain-behaviour modes of covariation in healthy and clinically depressed young people
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DOI：
10.1038/s41598-019-47277-3
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发表时间：
2019-08-08
影响因子：
4.6
通讯作者：
Mourao-Miranda, Janaina
中科院分区：
文献类型：
--
作者：
Mihalik, Agoston;Ferreira, Fabio S.;Mourao-Miranda, Janaina
了解心理测量学，智商和人口统计学维度的变化如何与青春期和成年早期关键发育期的大脑连接变化相关是一个重大挑战。这对精神健康障碍特别重要，因为不了解这些联系可能会阻碍更好的诊断方法和治疗方法的发展。在这里，我们调查了306青少年和年轻人（14- 24岁，25临床抑郁症）使用多变量统计框架，典型相关分析（CCA）的基础上这个问题。通过将个人功能性大脑连接概况与自我报告问卷、智商和人口统计数据联系起来，我们确定了两种不同的协变模式。第一种模式映射到外部化/内部化轴，并表现出强烈的关联性。第二种模式映射到独立于性别的幸福/痛苦轴上。有趣的是，这两种模式都与年龄有关。至关重要的是，与这些表型变化相关的功能性大脑连接的变化显示出显着的发育影响。这些发现指出了默认模式、额顶叶和边缘系统网络在精神病理学和抑郁症中的作用。
Understanding how variations in dimensions of psychometrics, IQ and demographics relate to changes in brain connectivity during the critical developmental period of adolescence and early adulthood is a major challenge. This has particular relevance for mental health disorders where a failure to understand these links might hinder the development of better diagnostic approaches and therapeutics. Here, we investigated this question in 306 adolescents and young adults (14-24y, 25 clinically depressed) using a multivariate statistical framework, based on canonical correlation analysis (CCA). By linking individual functional brain connectivity profiles to self-report questionnaires, IQ and demographic data we identified two distinct modes of covariation. The first mode mapped onto an externalization/internalization axis and showed a strong association with sex. The second mode mapped onto a well-being/distress axis independent of sex. Interestingly, both modes showed an association with age. Crucially, the changes in functional brain connectivity associated with changes in these phenotypes showed marked developmental effects. The findings point to a role for the default mode, frontoparietal and limbic networks in psychopathology and depression.