Sub-compartmental organization of Golgi-resident N-glycan processing enzymes in plants.
Sub-compartmental organization of Golgi-resident N-glycan processing enzymes in plants.
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DOI：
10.1093/mp/ssq082
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发表时间：
2011-03
期刊：
影响因子：
27.5
通讯作者：
Strasser R
中科院分区：
文献类型：
--
作者：
Schoberer J;Strasser R
在所有真核生物中，高尔基体是蛋白质糖基化的主要位点。广泛接受的是，发现参与N-聚糖加工的糖苷酶和糖基转移酶集中在高尔基体堆叠内，在那里它们提供它们的功能。这意味着催化加工途径中的早期步骤的酶主要位于顺式侧，而迟效酶主要位于堆叠的反式侧，从而产生沿高尔基体的顺式-反式轴沿着的不均匀分布。有令人信服的证据表明，它们的信息排序到特定的高尔基体池取决于信号编码的蛋白质本身，以及对运输机械，识别这些信号，它被认为是实现和保持池亚区室化的保留和检索机制的组合。然而，涉及的信号、机制和分子因素仍然未知。在这里，我们解决了最近的研究结果，并总结了目前的理解，这一基本过程中的植物细胞生物学。
In all eukaryotes, the Golgi apparatus is the main site of protein glycosylation. It is widely accepted that the glycosidases and glycosyltransferases involved in N-glycan processing are found concentrated within the Golgi stack where they provide their function. This means that enzymes catalyzing early steps in the processing pathway are located mainly at the cis-side, whereas late-acting enzymes mostly locate to the trans-side of the stacks, creating a non-uniform distribution along the cis–trans axis of the Golgi. There is compelling evidence that the information for their sorting to specific Golgi cisternae depends on signals encoded in the proteins themselves as well as on the trafficking machinery that recognizes these signals and it is believed that cisternal sub-compartmentalization is achieved and maintained by a combination of retention and retrieval mechanisms. Yet, the signals, mechanism(s), and molecular factors involved are still unknown. Here, we address recent findings and summarize the current understanding of this fundamental process in plant cell biology.
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DOI：
10.1073/pnas.0506958103
发表时间：
2006-04-25
影响因子：
11.1
作者：
Dunkley, TPJ;Hester, S;Lilley, KS
通讯作者：
Lilley, KS
影响因子：
3.9
作者：
Hawes, Chris;Schoberer, Jennifer;Osterrieder, Anne
通讯作者：
Osterrieder, Anne
影响因子：
27.5
作者：
Cubero, Beatriz;Nakagawa, Yuko;Pardo, Jose M.
通讯作者：
Pardo, Jose M.
影响因子：
7.4
作者：
Fitchette, AC;Cabanes-Macheteau, M;Hawes, C
通讯作者：
Hawes, C
影响因子：
11.6
作者：
Brandizzi, F;Frangne, N;Paris, N
通讯作者：
Paris, N