Regional intensive and temporal patterns of functional MRI activation distinguishing noxious and innocuous contact heat
Regional intensive and temporal patterns of functional MRI activation distinguishing noxious and innocuous contact heat
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DOI：
10.1152/jn.01025.2004
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发表时间：
2005-04-01
影响因子：
2.5
通讯作者：
Greenspan, JD
中科院分区：
文献类型：
--
作者：
Moulton, EA;Keaser, ML;Greenspan, JD
使用初级体感皮层（SI）和次级体感皮层（S2）的功能磁共振成像（fMRI）感兴趣区域分析（ROI）来测量皮质对疼痛和非疼痛热的反应。前扣带回 (ACC)。辅助运动区 (SMA)、岛叶和额内回 (IFG)。先前的研究表明，不同形式的无害和有害刺激会在 S1 和 S2 中产生不同时间进程的反应。本研究的目的是 1) 确定多个体感处理皮层区域是否会引起时间上不同的伤害性血氧水平依赖性 (BOLD) 反应，2) 这些反应是否能区分小的伤害性刺激强度差异。 33 名受试者接受了功能磁共振成像扫描，同时接受三种强度的热刺激，范围从无害的温暖（41 摄氏度）到低于耐受性 1 摄氏度，施加于左脚背。无害反应和有害反应在对侧 S1、中 ACC 和 SMA 中是可区分的。伤害性反应的峰值比无害反应峰值暂时延迟 6-8 秒。在对侧后岛叶中观察到对有害刺激的反应，但对无害刺激没有反应。对侧 S2 对无害和有害刺激的反应没有统计学差异。仅在对侧 S I 中，伤害感受反应可以区分相距 1 摄氏度的热刺激。这些结果表明，1）多个皮质区域具有暂时可区分的由令人痛苦的热热电极引起的无害和有害反应，2）不同皮质区域的伤害感受处理特性各不相同，3）S1 中的伤害感受反应以无与伦比的水平区分疼痛温度 其他皮质区域。
Cortical responses to painful and nonpainful heat were measured using functional magnetic resonance imaging (fMRI) region of interest analysis (ROI) of primary somatosensory cortex (SI), secondary somatosensory cortex (S2). antetior cingulate (ACC). supplementary motor area (SMA), insula, and interior frontal gyrus (IFG). Previous Studies indicated that innocuous and noxious stimuli of different modalities produce responses with different time courses in S1 and S2. The aim of this study was to 1) determine whether temporally distinct nociceptive blood oxygen level-dependent (BOLD) responses are evoked in multiple somatosensory processing cortical areas and 2) whether these responses discriminate small noxious stimulus intensity differences. Thirty-three subjects underwent fMRI scanning while receiving three intensities of thermal Stimuli, ranging from innocuous warm (41 degrees C) to 1 degrees C below tolerance, applied to the dorsum of the left foot. Innocuous and noxious responses were distinguishable in contralateral S1, the mid-ACC, and SMA. The peak of the nociceptive response was temporally delayed from the innocuous response peak by 6-8 s. Responses to noxious but not to innocuous stimuli were observed in contralateral posterior insula. Responses to innocuous and noxious stimuli were not statistically different ill contralateral S2. In contralateral S I only, the nociceptive response could differentiate heat stimuli separated by 1 degrees C. These results show that 1) multiple cortical areas have temporally distinguishable innocuous and noxious responses evoked by a painfully hot thermode, 2) the nociceptive processing properties vary across cortical regions, and 3) nociceptive responses in S1 discriminate between painful temperatures at a level unmatched ill other cortical areas.