Amygdala-Midbrain Connections Modulate Appetitive and Aversive Learning
Amygdala-Midbrain Connections Modulate Appetitive and Aversive Learning
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DOI：
10.1016/j.neuron.2020.03.016
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发表时间：
2020-06-17
期刊：
影响因子：
16.2
通讯作者：
Malenka, Robert C.
中科院分区：
文献类型：
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作者：
Steinberg, Elizabeth E.;Gore, Felicity;Malenka, Robert C.
中央杏仁核(CEA)协调对情绪事件的适应性反应。虽然防御行为的CEA底物已被广泛研究，但食欲行为的CEA回路及其与威胁反应回路的关系仍未明确。在这里，我们证明了CEA向黑质外侧区(SNL)发送强大的抑制投射，有助于小鼠的食欲和厌恶学习。CEA>；SNL对欲望和厌恶刺激的神经反应受期望和幅度的调节，这与群体水平的显著信号一致，这是巴甫洛夫条件化奖赏寻求和防御行为所必需的。当CEA-SNL末端激活与自愿行为联系在一起时，会引发强化，但未能支持依赖激励价值信号的巴甫洛夫关联。与去抑制机制一致，CEA输入优先针对SNL GABA神经元，CEA-和SNL多巴胺神经元对显著刺激的反应相似。总而言之，我们的结果表明，杏仁核的相互作用代表了一种以前未被认识到的影响情绪行为的机制。
The central amygdala (CeA) orchestrates adaptive responses to emotional events. While CeA substrates for defensive behaviors have been studied extensively, CeA circuits for appetitive behaviors and their relationship to threat-responsive circuits remain poorly defined. Here, we demonstrate that the CeA sends robust inhibitory projections to the lateral substantia nigra (SNL) that contribute to appetitive and aversive learning in mice. CeA -> SNL neural responses to appetitive and aversive stimuli were modulated by expectation and magnitude consistent with a population-level salience signal, which was required for Pavlovian conditioned reward-seeking and defensive behaviors. CeA -> SNL terminal activation elicited reinforcement when linked to voluntary actions but failed to support Pavlovian associations that rely on incentive value signals. Consistent with a disinhibitory mechanism, CeA inputs preferentially target SNL GABA neurons, and CeA -> SNL and SNL dopamine neurons respond similarly to salient stimuli. Collectively, our results suggest that amygdalanigra interactions represent a previously unappreciated mechanism for influencing emotional behaviors.