Genetic diversity in hepatitis C virus in Egypt and possible association with hepatocellular carcinoma
Genetic diversity in hepatitis C virus in Egypt and possible association with hepatocellular carcinoma
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DOI：
10.1099/vir.0.82626-0
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发表时间：
2007-05-01
影响因子：
3.8
通讯作者：
Widell, Anders
中科院分区：
文献类型：
--
作者：
Abdel-Hamid, Mohamed;El-Daly, Mai;Widell, Anders
Egypt has one of the world's highest prevalences of hepatitis C virus (HCV) infection, with a majority of genotype 4 infections. To explore the genetic diversity of HCV in Egypt, sera from 131 Egyptians [56 from community studies, 37 chronic hepatitis patients, 28 hepatocellular carcinoma (HCC) patients and 10 patients with non-Hodgkin's lymphoma] were genotyped by restriction fragment-length polymorphism and phylogenetic analyses of sequences from the mid-core and non-structural 5B regions. The different genotyping methods showed good agreement. The majority of the viruses (83 of 131; 63 %) were of subtype 4a, but five other subtypes within genotype 4 were also observed, as well as three genotype 1b, five genotype 1g and one genotype 3a samples. Interestingly, subtype 4o, which was easily identifiable in all three genomic regions, 3 showed an association with HCC (P=0.017), which merits further investigation.
