Evolution of transgenerational immunity in invertebrates
Evolution of transgenerational immunity in invertebrates
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DOI：
10.1098/rspb.2016.1136
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发表时间：
2016-09-28
影响因子：
4.7
通讯作者：
Gandon, S.
中科院分区：
文献类型：
--
作者：
Pigeault, R.;Garnier, R.;Gandon, S.
十多年前，无脊椎动物跨代免疫的发现改变了现有的免疫系统缺乏复杂性的范式。尽管如此，这种特征的普遍性和推动其在无脊椎动物中进化的生态因素仍然知之甚少。在这里，我们开发了一个理论宿主-寄生虫模型，并预测，长寿命和低扩散应促进跨代免疫的进化。我们还预测，在产生philopatric和分散的个人的物种，它可能会支付有一个塑料分配策略，在philopatric后代更高的跨代免疫投资，因为他们更有可能遇到当地适应的病原体。我们回顾了迄今为止发表的所有实验研究，包括21种无脊椎动物在9个不同的订单，我们表明，正如预期的那样，长寿和传播与免疫力转移到后代。我们预测的跨代免疫投资的可塑性的有效性仍有待测试，在无脊椎动物，但也在脊椎动物物种。我们讨论了我们的工作的免疫进化的研究的影响，我们建议进一步的研究途径，以扩大我们的跨代免疫保护在宿主-寄生虫相互作用的影响的知识。
Over a decade ago, the discovery of transgenerational immunity in invertebrates shifted existing paradigms on the lack of sophistication of their immune system. Nonetheless, the prevalence of this trait and the ecological factors driving its evolution in invertebrates remain poorly understood. Here, we develop a theoretical host-parasite model and predict that long lifespan and low dispersal should promote the evolution of transgenerational immunity. We also predict that in species that produce both philopatric and dispersing individuals, it may pay to have a plastic allocation strategy with a higher transgenerational immunity investment in philopatric offspring because they are more likely to encounter locally adapted pathogens. We review all experimental studies published to date, comprising 21 invertebrate species in nine different orders, and we show that, as expected, longevity and dispersal correlate with the transfer of immunity to offspring. The validity of our prediction regarding the plasticity of investment in transgenerational immunity remains to be tested in invertebrates, but also in vertebrate species. We discuss the implications of our work for the study of the evolution of immunity, and we suggest further avenues of research to expand our knowledge of the impact of transgenerational immune protection in host-parasite interactions.