New secondary metabolities from the endophytic fungus Aspergillus sp. from Tripterygium wilfordii
New secondary metabolities from the endophytic fungus Aspergillus sp. from Tripterygium wilfordii
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内生真菌曲霉菌的新次生代谢。
DOI：
10.1080/14786419.2020.1868464
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发表时间：
2021
影响因子：
2.2
通讯作者：
Yonghui Zhang
中科院分区：
文献类型：
--
作者：
Mengyi Deng;Xiaosheng Tan;Yuben Qiao;Weiguang Sun;Shuangshuang Xie;Zhengyi Shi;Yuanyuan Lu;Gang Chen;Changxing Qi;Yonghui Zhang
一个新的基于3，5-二甲基地衣酸（DMOA）的meroterpenoid（1），一个异戊二烯化色氨酸衍生物（2），以及10个已知化合物（3−12）从内生真菌gillussp中分离出来。从雷公藤。通过NMR、HRESIMS、UV和IR数据以及电子圆二色谱（ECD）计算确定了它们的结构和绝对构型。在结构上，化合物1是一个罕见的以DMOA为基础的酸稠合C/D环的类萜，化合物2具有一个罕见的（E）-肟基。在生物活性方面，洛伐他汀类似物5、6、9和10对抗CD 3/抗CD 28单克隆抗体刺激的小鼠脾细胞增殖具有潜在的免疫抑制活性，IC 50值范围为（5.30 ± 0.51）μM ~（16.51 ± 1.62）μM。
One new 3,5-dimethylorsellinic acid (DMOA)-based meroterpenoid (1), one prenylated tryptophan derivative (2), together with ten known compounds (3−12) were isolated from the endophytic fungusAspergillussp. fromTripterygium wilfordii. Their structures and absolute configurations were determined by NMR spectroscopic data, HRESIMS data, UV and IR data as well as electronic circular dichroism (ECD) calculation. In structure, compound1was a rare example of DMOA-based meroterpenoid with acis-fused C/D ring system, and compound2possessed an unusual (E)-oxime group. In bioactivity, the lovastatin analogues5,6,9and10showed potential immunosuppressive activity against anti-CD3/anti-CD28 monoclonal antibodies (mAbs)-irritated murine splenocytes proliferation, with IC50values ranging from (5.30 ± 0.51)μM to (16.51 ± 1.62)μM.