Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B: a case report.

Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B: a case report.
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与乙型肝炎治疗的骨质乳核酸治疗相关的骨质核酸骨骨折的病理股骨骨折:病例报告。

DOI:
10.1186/1746-1596-7-108
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发表时间:
2012-08-20
影响因子:
2.6
通讯作者:
Komiya S
Komiya S
中科院分区:
医学4区
文献类型:
--
作者:
Tanaka M;Setoguchi T;Ishidou Y;Arishima Y;Hirotsu M;Saitoh Y;Nakamura S;Kakoi H;Nagano S;Yokouchi M;Kamizono J;Komiya S

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我们报告一例62岁男性患者,因阿德福韦酯诱导的骨软化症导致病理性股骨颈骨折,行全髋关节置换术。他有13个月的肩、髋和膝关节骨痛史。在股骨颈骨折发生前,他接受阿德福韦酯治疗拉米夫定耐药的B型肝炎病毒感染5年。骨科医生应注意药物引起的肾功能不全引起的骨软化和病理性髋部骨折,这会导致范可尼综合征。本文的虚拟幻灯片可以在这里找到:http://www.diagnosticpathology.diagnomx.eu/vs/1600344696739249
We present a case of a 62-year-old man who underwent total hip arthroplasty for treatment of pathologic femoral neck fracture associated with adefovir dipivoxil-induced osteomalacia. He had a 13-month history of bone pain involving his shoulders, hips, and knee. He received adefovir dipivoxil for treatment of lamivudine-resistant hepatitis B virus infection for 5 years before the occurrence of femoral neck fracture. Orthopedic surgeons should be aware of osteomalacia and pathological hip fracture caused by drug-induced renal dysfunction, which results in Fanconi’s syndrome. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1600344696739249
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