Genetic changes of coxsackievirus A16 and enterovirus 71 isolated from hand, foot, and mouth disease patients in Toyama, Japan between 1981 and 2007.
Genetic changes of coxsackievirus A16 and enterovirus 71 isolated from hand, foot, and mouth disease patients in Toyama, Japan between 1981 and 2007.
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DOI：
10.7883/yoken.jjid.2009.254
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发表时间：
2009-07
影响因子：
2.2
通讯作者：
M. Iwai;Akio Masaki;S. Hasegawa;M. Obara;E. Horimoto;Kazuya Nakamura;Yuichi Tanaka;Kyoko Endo;Keiko Tanaka;J. Ueda;K. Shiraki;T. Kurata;T. Takizawa
中科院分区：
文献类型：
--
作者：
M. Iwai;Akio Masaki;S. Hasegawa;M. Obara;E. Horimoto;Kazuya Nakamura;Yuichi Tanaka;Kyoko Endo;Keiko Tanaka;J. Ueda;K. Shiraki;T. Kurata;T. Takizawa
我们对1981-2007年从富山手足口病患者中分离的柯萨奇病毒A16(CA16)和肠道病毒71(EV71)的完整VP1区进行了基因多样性分析，以评估流行与基因变化之间的关系。1995-1998年，CA16的优势基因群由B群变为C群，C群在2002年前后进一步由C亚群变为C2亚群，2005-2007年进一步由C亚群变为C3群。1983-1994年EV71亚群分为B1、B4、C1和C3亚群，1997-2006年分为C4亚群。然而，CA16的VP1区氨基酸序列的变化是恢复的，而EV71分离株的氨基酸序列在调查期间没有在相同的亚群中观察到，这表明间隔几年发生的流行似乎取决于免疫幼稚儿童的累积数量，而不是病毒抗原的变化。
We characterized the genetic diversity of the complete VP1 region of coxsackievirus A16 (CA16) and enterovirus 71 (EV71) isolated from patients with hand, foot, and mouth disease in Toyama from 1981 to 2007 to evaluate the relationship between epidemics and genetic changes. The predominant genogroups of CA16 changed from B to C in 1995-1998, and genogroup C further changed from subgenogroup C1 to C2 around 2002, and to C3 in 2005-2007. The subgenogroups of the EV71 isolates were classified into B1, B4, C1, and C3 in 1983-1994, and into C4 in 1997-2006. However, changes of the amino acid sequences of the VP1 regions of CA16 were restored, and those of the EV71 isolates were not observed among the same subgenogroups during this survey period, indicating that the prevalence that occurred at intervals of several years seemed to depend on an accumulating number of immunologically naive children, not viral antigenic changes.