The post-mortem incidence of focal thyroiditis.
The post-mortem incidence of focal thyroiditis.
复制标题
局灶性甲状腺炎的死后发病率。
DOI：
10.1002/path.1700830127
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发表时间：
1962
期刊：
影响因子：
--
通讯作者：
I. Doniach
中科院分区：
文献类型：
--
作者：
E. Williams;I. Doniach
材料和方法甲状腺来自Hammersmith医院的尸检。对1948-1953年间所有的甲状腺切片进行了研究。有40%的版面可用。在此期间进行的尸检。人们注意到，甲状腺组织的组织学保存更多地取决于进行检查的人，而不是疾病的性质，因此，由于我们正在研究的变化通常不会反映在腺体的任何宏观变化中，我们认为年龄和性别分布显示的趋势总体上是可靠的。将所研究的特殊疾病中的甲状腺炎发病率与一般系列提供的基线进行比较。每一张组织切片(HE染色)在低倍显微镜下进行系统检查，并估计每平方厘米厚切片上的淋巴细胞浸润灶的数目。应用的唯一标准是存在一组淋巴细胞或浆细胞，这些淋巴细胞或浆细胞很容易用低功率物镜观察到。滤泡破裂或嗜酸性粒细胞改变不被认为是诊断局灶性甲状腺炎的先决条件，尽管滤泡破裂几乎总是存在的，而且嗜氧性细胞变化频繁，出现在每平方英尺10个以上的病例中。厘米。每个部分都由两名观察员分别进行SCA检查，直到对该部分进行研究后才参考尸检结果。在普通系列中检查了724个甲状腺的切片；其中612个来自20岁或以上的患者。
MATERIALS AND METHODSThe thyroids were from necropsies at Hammersmith Hospital. All thyroids sectioned over a period of 5 years (1948-1953) were studied. Sections were available in 40 per cent. of the necropsies carried out during this period. The preservation of thyroid tissue for histology was noted to depend more on the person carrying out the examination than on the nature of the disease, and because of this, and because the change that we were studying was not usually reflected by any macroscopic alteration in the gland, we consider that the trends shown in the age and sex distribution are generally reliable. The incidence of thyroiditis in the special diseases studied was compared with the baseline afforded by the general series. Each histological section (stained with hEmalum and eosin) was systematically examined under the low power of the microscope, and the number of foci of lymphocytic infiltration per square centimetre area of the Gp-thick section estimated. The sole criterion applied was the presence of a collection of lymphocytes or plasma cells easily visible with a, low-power objective. The presence of follicle breakdown or oxyphil cell change was not considered a prerequisite for the diagnosis of focal thyroiditisalthough folliclebreakdown was almost invariably, and oxyphil change frequently, present in those cases with more than 10 foci per sq. cm. Each section was sca, nned by two observers separately, and the necropsy findings were not consulted until after the section had been studied. Sections from 724 thyroids were examined in the general series; of these 612 were from patients aged 20 or over.