Low serum selenium concentration is associated with preeclampsia in pregnant women from Bangladesh
Low serum selenium concentration is associated with preeclampsia in pregnant women from Bangladesh
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DOI：
10.1016/j.jtemb.2015.08.002
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发表时间：
2016-01-01
影响因子：
3.5
通讯作者：
Islam, Mohammad Safiqul
中科院分区：
文献类型：
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作者：
Haque, Md Mahmodul;Moghal, Md Mizanur Rahman;Islam, Mohammad Safiqul
目的：子痫前期是一种妊娠期高血压疾病，是孕产妇和围产期死亡及早产的主要原因之一，特别是在低收入和中等收入国家。硒是硒蛋白的重要组成部分，具有抗氧化和多种代谢功能。本研究通过测定子痫前期患者血清硒浓度，探讨硒在子痫前期的作用。方法：本研究采用病例对照研究的方法，将74例妊娠20周的先兆子痫患者（轻度52例，重度22例）和118例相同妊娠期的正常孕妇作为对照。在常规医院就诊时详细记录患者病史。采用原子吸收光谱法测定血清硒浓度。统计分析采用SPSS统计软件包（version 16）进行独立样本t检验和Pearson相关检验。结果：我们的研究发现，子痫前期患者的平均血清硒浓度显著低于健康孕妇（p < 0.05）。进一步分析硒浓度与疾病严重程度的关系，发现重度子痫前期患者硒浓度明显低于轻度子痫前期患者（p < 0.05）。Pearson相关分析显示，硒与收缩压（r = -0.419, p =0.001）、舒张压（r = -0.392, p =0.001）、妊娠期（r = -0.218, p =0.001）呈显著负相关。结论：本研究发现子痫前期患者血清硒浓度低于正常孕妇。(C) 2015 Elsevier GmbH版权所有。
Objectives: Preeclampsia is a hypertensive disorder of pregnancy which is one of the leading causes of maternal and perinatal mortality and pre-term delivery, especially in low and middle income countries. Selenium is an important constituent of selenoproteins that act as antioxidant and have several metabolic functions. The present study was conducted to determine serum selenium concentration in preeclampsia patients in order to find out the role of selenium in preeclampsia.Methods: This study was conducted as case-control study with 74 preeclampsia patients as cases whose gestation were >= 20 weeks (52 mild and 22 severe patients) and 118 normotensive pregnant women as controls from same gestational period. Detailed patient history was recorded during routine hospital visits. Serum selenium concentration was determined by using atomic absorption spectroscopy. Independent sample t-test and Pearson's correlation test were done for the statistical analysis using the statistical software package SPSS, version 16.Results: Our study found that mean serum concentration of selenium in preeclampsia patients was significantly lower than that of healthy pregnant women (p < 0.05). Further analysis for selenium concentration with disease severity explored that selenium concentration was significantly lower in severe preeclampsia in comparison to mild preeclampsia (p 0.05). Pearson's correlation analysis reveals significant negative correlation of selenium with systolic blood pressure (r = -0.419, p = 0.001), diastolic blood pressure (r = -0.392, p =0.001), and gestational period (r = -0.218, p = 0.001).Conclusion: Our study found that preeclampsia patients have decreased serum selenium concentration than the healthy pregnant women. (C) 2015 Elsevier GmbH. All rights reserved.