Do 'passive' medical titanium surfaces deteriorate in service in the absence of wear?
Do 'passive' medical titanium surfaces deteriorate in service in the absence of wear?
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DOI：
10.1098/rsif.2012.0438
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发表时间：
2012-11-07
影响因子：
3.9
通讯作者：
Martin, R. A.
中科院分区：
文献类型：
--
作者：
Addison, O.;Davenport, A. J.;Martin, R. A.
在全球范围内，每年有超过1000吨的钛（Ti）以生物医学装置的形式植入患者体内。钛被认为是“生物相容性”的，因为它有一个坚固的被动氧化膜(大约。4纳米厚)在金属表面。然而，表面恶化会导致Ti离子的释放，并且由于磨损和/或腐蚀过程会产生颗粒。这种表面恶化可导致种植体周围炎症，导致植入装置过早丢失或需要手术翻修。采用同步加速器x射线微荧光光谱和x射线吸收近边结构对商用纯颅骨锚定装置（骨锚定助听器）周围软组织进行了研究。在这里，我们提出了第一个实验证据，证明最小负荷的钛植入物，不受宏观磨损过程的影响，可以将钛碎片释放到周围的软组织中。由于这些碎片已被证明具有促炎作用，我们认为钛的这种分布可能会影响设备的使用寿命。
Globally, more than 1000 tonnes of titanium (Ti) is implanted into patients in the form of biomedical devices on an annual basis. Ti is perceived to be 'biocompatible' owing to the presence of a robust passive oxide film (approx. 4 nm thick) at the metal surface. However, surface deterioration can lead to the release of Ti ions, and particles can arise as the result of wear and/or corrosion processes. This surface deterioration can result in peri-implant inflammation, leading to the premature loss of the implanted device or the requirement for surgical revision. Soft tissues surrounding commercially pure cranial anchorage devices (bone-anchored hearing aid) were investigated using synchrotron X-ray micro-fluorescence spectroscopy and X-ray absorption near edge structure. Here, we present the first experimental evidence that minimal load-bearing Ti implants, which are not subjected to macroscopic wear processes, can release Ti debris into the surrounding soft tissue. As such debris has been shown to be pro-inflammatory, we propose that such distributions of Ti are likely to effect to the service life of the device.