A simplified technique for heart transplantation in rats: Abdominal vessel branch-sparing and modified venotomy
A simplified technique for heart transplantation in rats: Abdominal vessel branch-sparing and modified venotomy
复制标题
DOI：
10.1002/micr.20272
复制
发表时间：
2006-01-01
期刊：
影响因子：
2.1
通讯作者：
Terness, Peter
中科院分区：
文献类型：
--
作者：
Wang, Daohu;Opelz, Gerhard;Terness, Peter
自从小野和林赛发表他们的技术以来，大鼠异位心脏移植已成为免疫学中广泛使用的模型。然而，不同作者使用这种方法报告的移植物存活率存在差异。随着显微外科和新仪器的发展，这项技术的改进成为可能。作者描述了一种改进的 Ono-Lindsey 方法，该方法基于保留分支和静脉切开术的修改，可显着缩短缺血（25 分钟）和手术时间（40 分钟），最大限度地减少术后并发症，并显着提高移植物存活率。 (c) 2006 Wiley-Liss, Inc.
Heterotopic heart transplantation in rats has been a widely used model in immunology since Ono and Lindsey published their technique. However, variable graft survival rates were reported by different authors with this method. With the development of microsurgery and new instruments, amendment of this technique became possible. The authors described an improved Ono-Lindsey method, based on branchsparing and venotomy modifications, leading to a significantly shortened ischemia (25 min) and operation time (40 min), minimal postoperative complications, and considerably improved graft survival. (c) 2006 Wiley-Liss, Inc.